FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022698715> ?p ?o ?g. }

• W2022698715 endingPage "305" @default.
• W2022698715 startingPage "297" @default.
• W2022698715 abstract "Isolated livers of normal and hypophysectomized (hypox) rats with or without GH replacement therapy were perfused in an erythrocyte-free recirculating perfusion system for 4 h in the presence of [35S]cysteine. Albumin secretion and synthesis increased in a parallel and linear fashion over 4 h. The albumin secretion rates were 0.53 and 0.21 mg/g liver h-1 in normal and hypox animals, respectively. Insulin-like growth factor (IGF) secretion, measured as insulin equivalents in the fat cell assay as well as in a competitive protein binding assay, and IGF synthesis, as determined from [35S]cysteine incorporation into immunoprecipitable IGF, likewise increased linearly and in parallel throughout the perfusion time. The IGF secretion rate was 50 microU/g liver h-1. The secreted IGF had a molecular weight of approximately 7700 daltons. Secretion and synthesis of IGF were reduced to 11% in hypox rats and were largely restored by human GH replacement therapy (to 86% of normal). A single specific binding protein with an approximate molecular weight of 35,000 was detected in the perfusate. The binding protein was measured by covalent cross-linkage to [125I]IGF I by dimethylsuberimidate. The secretion of this binding protein was 62% of normal in hypox animals and 79% in GH-treated hypox rats. The data suggest that IGF is continuously synthesized and released by the liver. Assuming a half-life for IGF of 3 h in the normal rat, a plasma volume of 8 ml, and a liver weight of 8.5 g, the rate of IGF production by the perfused normal rat liver (50 microU/g liver h-1) would be sufficient to maintain serum IGF at the concentration determined in normal rat serum (approximately 130 microU/ml). This suggests that the liver is the major site of IGF production in the rat." @default.
• W2022698715 created "2016-06-24" @default.
• W2022698715 creator A5013480346 @default.
• W2022698715 creator A5045672839 @default.
• W2022698715 creator A5088576664 @default.
• W2022698715 creator A5091528490 @default.
• W2022698715 date "1983-07-01" @default.
• W2022698715 modified "2023-10-16" @default.
• W2022698715 title "Synthesis and Secretion of Insulin-Like Growth Factor and Its Binding Protein by the Perfused Rat Liver: Dependence on Growth Hormone Status^*" @default.
• W2022698715 cites W103106123 @default.
• W2022698715 cites W14648726 @default.
• W2022698715 cites W148479160 @default.
• W2022698715 cites W1488424161 @default.
• W2022698715 cites W1512435793 @default.
• W2022698715 cites W1548747649 @default.
• W2022698715 cites W1567712837 @default.
• W2022698715 cites W1575604311 @default.
• W2022698715 cites W1580591685 @default.
• W2022698715 cites W1594575060 @default.
• W2022698715 cites W1775749144 @default.
• W2022698715 cites W1972454974 @default.
• W2022698715 cites W1991256647 @default.
• W2022698715 cites W2007441634 @default.
• W2022698715 cites W2008115139 @default.
• W2022698715 cites W2010577174 @default.
• W2022698715 cites W2011184872 @default.
• W2022698715 cites W2014493428 @default.
• W2022698715 cites W2017638235 @default.
• W2022698715 cites W2020151384 @default.
• W2022698715 cites W2020635408 @default.
• W2022698715 cites W2029425460 @default.
• W2022698715 cites W2037737006 @default.
• W2022698715 cites W2041578117 @default.
• W2022698715 cites W2045383371 @default.
• W2022698715 cites W2048727629 @default.
• W2022698715 cites W2065603997 @default.
• W2022698715 cites W2072159062 @default.
• W2022698715 cites W2080339426 @default.
• W2022698715 cites W2086778695 @default.
• W2022698715 cites W2087599581 @default.
• W2022698715 cites W2088203325 @default.
• W2022698715 cites W2098353733 @default.
• W2022698715 cites W2100837269 @default.
• W2022698715 cites W2132374234 @default.
• W2022698715 cites W2138360608 @default.
• W2022698715 cites W2238714245 @default.
• W2022698715 cites W2281337089 @default.
• W2022698715 cites W2289622023 @default.
• W2022698715 cites W2336874588 @default.
• W2022698715 cites W23677650 @default.
• W2022698715 cites W2410294229 @default.
• W2022698715 doi "https://doi.org/10.1210/endo-113-1-297" @default.
• W2022698715 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6190641" @default.
• W2022698715 hasPublicationYear "1983" @default.
• W2022698715 type Work @default.
• W2022698715 sameAs 2022698715 @default.
• W2022698715 citedByCount "438" @default.
• W2022698715 countsByYear W20226987152012 @default.
• W2022698715 countsByYear W20226987152013 @default.
• W2022698715 countsByYear W20226987152014 @default.
• W2022698715 countsByYear W20226987152015 @default.
• W2022698715 countsByYear W20226987152016 @default.
• W2022698715 countsByYear W20226987152017 @default.
• W2022698715 countsByYear W20226987152018 @default.
• W2022698715 countsByYear W20226987152019 @default.
• W2022698715 countsByYear W20226987152020 @default.
• W2022698715 countsByYear W20226987152021 @default.
• W2022698715 countsByYear W20226987152022 @default.
• W2022698715 crossrefType "journal-article" @default.
• W2022698715 hasAuthorship W2022698715A5013480346 @default.
• W2022698715 hasAuthorship W2022698715A5045672839 @default.
• W2022698715 hasAuthorship W2022698715A5088576664 @default.
• W2022698715 hasAuthorship W2022698715A5091528490 @default.
• W2022698715 hasConcept C104317684 @default.
• W2022698715 hasConcept C126322002 @default.
• W2022698715 hasConcept C134018914 @default.
• W2022698715 hasConcept C146957229 @default.
• W2022698715 hasConcept C170493617 @default.
• W2022698715 hasConcept C181199279 @default.
• W2022698715 hasConcept C185592680 @default.
• W2022698715 hasConcept C2775960820 @default.
• W2022698715 hasConcept C2776125364 @default.
• W2022698715 hasConcept C2779201268 @default.
• W2022698715 hasConcept C2779306644 @default.
• W2022698715 hasConcept C2780378035 @default.
• W2022698715 hasConcept C2780689927 @default.
• W2022698715 hasConcept C2984496839 @default.
• W2022698715 hasConcept C49039625 @default.
• W2022698715 hasConcept C553089730 @default.
• W2022698715 hasConcept C55493867 @default.
• W2022698715 hasConcept C71315377 @default.
• W2022698715 hasConcept C71924100 @default.
• W2022698715 hasConcept C80862487 @default.
• W2022698715 hasConcept C86803240 @default.
• W2022698715 hasConceptScore W2022698715C104317684 @default.
• W2022698715 hasConceptScore W2022698715C126322002 @default.
• W2022698715 hasConceptScore W2022698715C134018914 @default.
• W2022698715 hasConceptScore W2022698715C146957229 @default.

• next