Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022700601> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2022700601 endingPage "215" @default.
- W2022700601 startingPage "210" @default.
- W2022700601 abstract "Parathyroid hormone (PTH) suppression in patients with end-stage renal disease (ESRD) undergoing maintenance hemodialysis is achieved largely by the use of intravenous calcitriol. Aspects of the utility and efficacy of this therapy remain controversial. It is debated whether oral versus intravenous therapy is more effective. Most existing studies examine the effect of calcitriol in isolation, without adjusting for other factors that might influence PTH levels. Thus, the simultaneous role of factors such as dosing, control of serum calcium and phosphorus, and demographic variables such as age, sex, race, and duration of ESRD is not well understood.We examined the relationship between the administration of calcitriol and PTH suppression in a cohort of hemodialysis patients at a large urban dialysis facility over a period of 30 months. Hemodialysis patients (n = 155) who received at least 3 months of treatment in this facility were included.Using a time sensitive multiple linear regression modeling technique, we found that second and subsequent PTH levels were positively correlated with black race (P < 0.0001) and serum phosphate (P < 0.03) and strongly negatively correlated with serum calcium (P< 0.0001) and diabetes (P< 0.0039). Drug dose (in micrograms per kilogram per month) was weakly negatively correlated (P < 0.04). Unlike previous studies, we adjusted for the simultaneous confounding influence of demographic and laboratory variables, as well as for drug dose normalized for body weight.This analysis suggests that calcitriol therapy in hemodialysis patients is adversely affected by higher phosphate levels and needs to account for such patient characteristics as race and diabetes and such laboratory variables as calcium and phosphate control. Finally, as has been recently suggested by others, the patient's race may require us to aim for different PTH target levels with therapy." @default.
- W2022700601 created "2016-06-24" @default.
- W2022700601 creator A5010070478 @default.
- W2022700601 creator A5027981249 @default.
- W2022700601 creator A5035973749 @default.
- W2022700601 creator A5046745848 @default.
- W2022700601 date "2002-04-01" @default.
- W2022700601 modified "2023-09-25" @default.
- W2022700601 title "Parathyroid Hormone Suppression by Intravenous Calcitriol: Role of Phosphate, Calcium, Race and Diabetes" @default.
- W2022700601 cites W1895667848 @default.
- W2022700601 cites W1977864809 @default.
- W2022700601 cites W1978136073 @default.
- W2022700601 cites W1980867224 @default.
- W2022700601 cites W1988793415 @default.
- W2022700601 cites W1990254836 @default.
- W2022700601 cites W2010916244 @default.
- W2022700601 cites W2019678067 @default.
- W2022700601 cites W2030392286 @default.
- W2022700601 cites W2042428144 @default.
- W2022700601 cites W2044458288 @default.
- W2022700601 cites W2044727825 @default.
- W2022700601 cites W2051763530 @default.
- W2022700601 cites W2055923382 @default.
- W2022700601 cites W2057254931 @default.
- W2022700601 cites W2082708611 @default.
- W2022700601 cites W2089345381 @default.
- W2022700601 cites W2094803889 @default.
- W2022700601 cites W2113015183 @default.
- W2022700601 cites W2149860264 @default.
- W2022700601 cites W2156887647 @default.
- W2022700601 doi "https://doi.org/10.1097/00000441-200204000-00008" @default.
- W2022700601 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12003377" @default.
- W2022700601 hasPublicationYear "2002" @default.
- W2022700601 type Work @default.
- W2022700601 sameAs 2022700601 @default.
- W2022700601 citedByCount "5" @default.
- W2022700601 crossrefType "journal-article" @default.
- W2022700601 hasAuthorship W2022700601A5010070478 @default.
- W2022700601 hasAuthorship W2022700601A5027981249 @default.
- W2022700601 hasAuthorship W2022700601A5035973749 @default.
- W2022700601 hasAuthorship W2022700601A5046745848 @default.
- W2022700601 hasConcept C126322002 @default.
- W2022700601 hasConcept C134018914 @default.
- W2022700601 hasConcept C2776079296 @default.
- W2022700601 hasConcept C2777288759 @default.
- W2022700601 hasConcept C2778063415 @default.
- W2022700601 hasConcept C2778653478 @default.
- W2022700601 hasConcept C2779978075 @default.
- W2022700601 hasConcept C2781208988 @default.
- W2022700601 hasConcept C3019040382 @default.
- W2022700601 hasConcept C519063684 @default.
- W2022700601 hasConcept C555293320 @default.
- W2022700601 hasConcept C71924100 @default.
- W2022700601 hasConcept C72563966 @default.
- W2022700601 hasConceptScore W2022700601C126322002 @default.
- W2022700601 hasConceptScore W2022700601C134018914 @default.
- W2022700601 hasConceptScore W2022700601C2776079296 @default.
- W2022700601 hasConceptScore W2022700601C2777288759 @default.
- W2022700601 hasConceptScore W2022700601C2778063415 @default.
- W2022700601 hasConceptScore W2022700601C2778653478 @default.
- W2022700601 hasConceptScore W2022700601C2779978075 @default.
- W2022700601 hasConceptScore W2022700601C2781208988 @default.
- W2022700601 hasConceptScore W2022700601C3019040382 @default.
- W2022700601 hasConceptScore W2022700601C519063684 @default.
- W2022700601 hasConceptScore W2022700601C555293320 @default.
- W2022700601 hasConceptScore W2022700601C71924100 @default.
- W2022700601 hasConceptScore W2022700601C72563966 @default.
- W2022700601 hasIssue "4" @default.
- W2022700601 hasLocation W20227006011 @default.
- W2022700601 hasLocation W20227006012 @default.
- W2022700601 hasOpenAccess W2022700601 @default.
- W2022700601 hasPrimaryLocation W20227006011 @default.
- W2022700601 hasRelatedWork W193647379 @default.
- W2022700601 hasRelatedWork W1949967542 @default.
- W2022700601 hasRelatedWork W1969959310 @default.
- W2022700601 hasRelatedWork W1990254836 @default.
- W2022700601 hasRelatedWork W1997341767 @default.
- W2022700601 hasRelatedWork W2028557808 @default.
- W2022700601 hasRelatedWork W2038986027 @default.
- W2022700601 hasRelatedWork W2040447463 @default.
- W2022700601 hasRelatedWork W2049887495 @default.
- W2022700601 hasRelatedWork W2057112909 @default.
- W2022700601 hasRelatedWork W2072072788 @default.
- W2022700601 hasRelatedWork W2074326126 @default.
- W2022700601 hasRelatedWork W2093769583 @default.
- W2022700601 hasRelatedWork W2094230172 @default.
- W2022700601 hasRelatedWork W2141331501 @default.
- W2022700601 hasRelatedWork W2166290832 @default.
- W2022700601 hasRelatedWork W2257317515 @default.
- W2022700601 hasRelatedWork W2259468377 @default.
- W2022700601 hasRelatedWork W2969995673 @default.
- W2022700601 hasRelatedWork W3022943634 @default.
- W2022700601 hasVolume "323" @default.
- W2022700601 isParatext "false" @default.
- W2022700601 isRetracted "false" @default.
- W2022700601 magId "2022700601" @default.
- W2022700601 workType "article" @default.