Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022700801> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2022700801 endingPage "232" @default.
- W2022700801 startingPage "223" @default.
- W2022700801 abstract "The objective of the study was to evaluate the structure-activity relationship for the antigenic activity of different organic acid anhydrides (OAAs). The specificity of guinea pig (GP) IgG1 to different anhydrides was studied by ELISA-inhibition, PCA, and airway provocation tests of cross-reactivity with different OAA conjugates. In the airway provocation tests, lung resistance and plasma extravasation of Evan's Blue dye was measured. The ELISA-inhibition tests showed a wide range in antibody specificity. Modelling of ring configuration, methyl group substitution, double bond position, and cis/trans isomerism of anhydride forming carboxyl groups influenced the specificity. There was a general consistency in cross-reactivity of anti-cis-hexahydrophthalic anhydride IgG1 versus GP serum albumin conjugates of trans-hexahydrophthalic anhydride, phthalic anhydride, and succinic anhydride as shown by ELISA-inhibition, PCA, and airway provocation tests. It is concluded that various modifications of the chemical structures of a hapten are recognized by the hapten-specific antibodies, and that these differences may have clinical relevance. In particular, the ring structure and the positions of double bonds and of methyl groups are important. Further, the in-vitro ELISA-inhibition tests show a good agreement with the in-vivo PCA and bronchial provocation tests." @default.
- W2022700801 created "2016-06-24" @default.
- W2022700801 creator A5001571542 @default.
- W2022700801 creator A5014442720 @default.
- W2022700801 creator A5031530786 @default.
- W2022700801 creator A5033272471 @default.
- W2022700801 date "1997-03-01" @default.
- W2022700801 modified "2023-10-16" @default.
- W2022700801 title "Antibody specificity to the chemical structures of organic acid anhydrides studied by in-vitro and in-vivo methods" @default.
- W2022700801 cites W1969013839 @default.
- W2022700801 cites W1971984979 @default.
- W2022700801 cites W2020718845 @default.
- W2022700801 cites W2056367638 @default.
- W2022700801 cites W2090461253 @default.
- W2022700801 cites W2119843803 @default.
- W2022700801 cites W2134001252 @default.
- W2022700801 doi "https://doi.org/10.1016/s0300-483x(96)03605-0" @default.
- W2022700801 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9129176" @default.
- W2022700801 hasPublicationYear "1997" @default.
- W2022700801 type Work @default.
- W2022700801 sameAs 2022700801 @default.
- W2022700801 citedByCount "17" @default.
- W2022700801 countsByYear W20227008012012 @default.
- W2022700801 countsByYear W20227008012013 @default.
- W2022700801 countsByYear W20227008012021 @default.
- W2022700801 crossrefType "journal-article" @default.
- W2022700801 hasAuthorship W2022700801A5001571542 @default.
- W2022700801 hasAuthorship W2022700801A5014442720 @default.
- W2022700801 hasAuthorship W2022700801A5031530786 @default.
- W2022700801 hasAuthorship W2022700801A5033272471 @default.
- W2022700801 hasConcept C110586980 @default.
- W2022700801 hasConcept C142724271 @default.
- W2022700801 hasConcept C150903083 @default.
- W2022700801 hasConcept C159654299 @default.
- W2022700801 hasConcept C161790260 @default.
- W2022700801 hasConcept C178790620 @default.
- W2022700801 hasConcept C185592680 @default.
- W2022700801 hasConcept C202751555 @default.
- W2022700801 hasConcept C203014093 @default.
- W2022700801 hasConcept C204787440 @default.
- W2022700801 hasConcept C207001950 @default.
- W2022700801 hasConcept C2777735259 @default.
- W2022700801 hasConcept C2778226065 @default.
- W2022700801 hasConcept C2779854550 @default.
- W2022700801 hasConcept C29144244 @default.
- W2022700801 hasConcept C55493867 @default.
- W2022700801 hasConcept C71240020 @default.
- W2022700801 hasConcept C71924100 @default.
- W2022700801 hasConcept C86803240 @default.
- W2022700801 hasConcept C86807702 @default.
- W2022700801 hasConceptScore W2022700801C110586980 @default.
- W2022700801 hasConceptScore W2022700801C142724271 @default.
- W2022700801 hasConceptScore W2022700801C150903083 @default.
- W2022700801 hasConceptScore W2022700801C159654299 @default.
- W2022700801 hasConceptScore W2022700801C161790260 @default.
- W2022700801 hasConceptScore W2022700801C178790620 @default.
- W2022700801 hasConceptScore W2022700801C185592680 @default.
- W2022700801 hasConceptScore W2022700801C202751555 @default.
- W2022700801 hasConceptScore W2022700801C203014093 @default.
- W2022700801 hasConceptScore W2022700801C204787440 @default.
- W2022700801 hasConceptScore W2022700801C207001950 @default.
- W2022700801 hasConceptScore W2022700801C2777735259 @default.
- W2022700801 hasConceptScore W2022700801C2778226065 @default.
- W2022700801 hasConceptScore W2022700801C2779854550 @default.
- W2022700801 hasConceptScore W2022700801C29144244 @default.
- W2022700801 hasConceptScore W2022700801C55493867 @default.
- W2022700801 hasConceptScore W2022700801C71240020 @default.
- W2022700801 hasConceptScore W2022700801C71924100 @default.
- W2022700801 hasConceptScore W2022700801C86803240 @default.
- W2022700801 hasConceptScore W2022700801C86807702 @default.
- W2022700801 hasIssue "2-3" @default.
- W2022700801 hasLocation W20227008011 @default.
- W2022700801 hasLocation W20227008012 @default.
- W2022700801 hasOpenAccess W2022700801 @default.
- W2022700801 hasPrimaryLocation W20227008011 @default.
- W2022700801 hasRelatedWork W2009699409 @default.
- W2022700801 hasRelatedWork W2011949324 @default.
- W2022700801 hasRelatedWork W2022700801 @default.
- W2022700801 hasRelatedWork W2051697617 @default.
- W2022700801 hasRelatedWork W2084693878 @default.
- W2022700801 hasRelatedWork W2348148517 @default.
- W2022700801 hasRelatedWork W2581070244 @default.
- W2022700801 hasRelatedWork W2950305852 @default.
- W2022700801 hasRelatedWork W2952759454 @default.
- W2022700801 hasRelatedWork W722593 @default.
- W2022700801 hasVolume "118" @default.
- W2022700801 isParatext "false" @default.
- W2022700801 isRetracted "false" @default.
- W2022700801 magId "2022700801" @default.
- W2022700801 workType "article" @default.