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• W2022703374 abstract "The effects on leucocyte motility of sulphasalazine (Salazopyrin) and its metabolites sulphapyridine and 5 amino-salicylic acid have been compared with those of prednisolone and indomethacin. Sulphasalazine, its active metabolite 5 amino-salicylic acid, and prednisolone are all potent inhibitors of leucocyte motility. Sulphapyridine and indomethacin are non-inhibitory. Inhibition of leucocyte motility may explain why sulphasalazine and 5 amino-salicylic acid are effective in ulcerative colitis while sulphapyridine is not. The lack of effect of indomethacin suggests that this action of sulphasalazine does not involve inhibition of prostaglandin synthesis." @default.
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• W2022703374 date "1981-08-01" @default.
• W2022703374 modified "2023-09-30" @default.
• W2022703374 title "Inhibition of leucocyte motility by drugs used in ulcerative colitis." @default.
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• W2022703374 doi "https://doi.org/10.1136/gut.22.8.642" @default.
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