Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022705009> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2022705009 endingPage "5" @default.
- W2022705009 startingPage "1" @default.
- W2022705009 abstract "Neuronal microtubules support intracellular transport, facilitate axon growth, and form a basis for neuronal morphology. While microtubules in nonneuronal cells are depolymerized by cold, Ca2+, or antimitotic drugs, neuronal microtubules are unusually stable. Such stability is important for normal axon growth and maintenance, while hyperstability may compromise neuronal function in aging and degeneration. Though mechanisms for stability are unclear, studies suggest that stable microtubules contain biochemically distinct tubulins that are more basic than conventional tubulins. Transglutaminase-catalyzed posttranslational incorporation of polyamines is one of the few modifications of intracellular proteins that add positive charges. Here we show that neuronal tubulin can be polyaminated by transglutaminase. Endogenous brain transglutaminase-catalyzed polyaminated tubulins have the biochemical characteristics of neuronal stable microtubules. Inhibiting polyamine synthesis or transglutaminase activity significantly decreases microtubule stability in vitro and in vivo. Together, these findings suggest that transglutaminase-catalyzed polyamination of tubulins stabilizes microtubules essential for unique neuronal structures and functions." @default.
- W2022705009 created "2016-06-24" @default.
- W2022705009 creator A5051052158 @default.
- W2022705009 creator A5074569290 @default.
- W2022705009 creator A5086218531 @default.
- W2022705009 date "2002-01-01" @default.
- W2022705009 modified "2023-10-16" @default.
- W2022705009 title "The role of transglutaminases in neurodegenerative diseases: overview" @default.
- W2022705009 cites W1592565027 @default.
- W2022705009 cites W1963870453 @default.
- W2022705009 cites W1978580506 @default.
- W2022705009 cites W1999363942 @default.
- W2022705009 cites W2009162588 @default.
- W2022705009 cites W2009190820 @default.
- W2022705009 cites W2015186431 @default.
- W2022705009 cites W2020206460 @default.
- W2022705009 cites W2032161390 @default.
- W2022705009 cites W2032255653 @default.
- W2022705009 cites W2032618784 @default.
- W2022705009 cites W2043899474 @default.
- W2022705009 cites W2049211009 @default.
- W2022705009 cites W2051788484 @default.
- W2022705009 cites W2053155552 @default.
- W2022705009 cites W2058731494 @default.
- W2022705009 cites W2064804771 @default.
- W2022705009 cites W2067161006 @default.
- W2022705009 cites W2073255828 @default.
- W2022705009 cites W2075990091 @default.
- W2022705009 cites W2078436452 @default.
- W2022705009 cites W2079813087 @default.
- W2022705009 cites W2120325083 @default.
- W2022705009 cites W2157513658 @default.
- W2022705009 cites W2412895198 @default.
- W2022705009 cites W4244779656 @default.
- W2022705009 cites W4383673615 @default.
- W2022705009 doi "https://doi.org/10.1016/s0197-0186(01)00055-9" @default.
- W2022705009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11738467" @default.
- W2022705009 hasPublicationYear "2002" @default.
- W2022705009 type Work @default.
- W2022705009 sameAs 2022705009 @default.
- W2022705009 citedByCount "21" @default.
- W2022705009 countsByYear W20227050092012 @default.
- W2022705009 countsByYear W20227050092013 @default.
- W2022705009 countsByYear W20227050092014 @default.
- W2022705009 countsByYear W20227050092018 @default.
- W2022705009 crossrefType "journal-article" @default.
- W2022705009 hasAuthorship W2022705009A5051052158 @default.
- W2022705009 hasAuthorship W2022705009A5074569290 @default.
- W2022705009 hasAuthorship W2022705009A5086218531 @default.
- W2022705009 hasConcept C12554922 @default.
- W2022705009 hasConcept C169760540 @default.
- W2022705009 hasConcept C178498320 @default.
- W2022705009 hasConcept C181199279 @default.
- W2022705009 hasConcept C185592680 @default.
- W2022705009 hasConcept C20418707 @default.
- W2022705009 hasConcept C2779530196 @default.
- W2022705009 hasConcept C55493867 @default.
- W2022705009 hasConcept C79879829 @default.
- W2022705009 hasConcept C84425145 @default.
- W2022705009 hasConcept C86803240 @default.
- W2022705009 hasConcept C95444343 @default.
- W2022705009 hasConceptScore W2022705009C12554922 @default.
- W2022705009 hasConceptScore W2022705009C169760540 @default.
- W2022705009 hasConceptScore W2022705009C178498320 @default.
- W2022705009 hasConceptScore W2022705009C181199279 @default.
- W2022705009 hasConceptScore W2022705009C185592680 @default.
- W2022705009 hasConceptScore W2022705009C20418707 @default.
- W2022705009 hasConceptScore W2022705009C2779530196 @default.
- W2022705009 hasConceptScore W2022705009C55493867 @default.
- W2022705009 hasConceptScore W2022705009C79879829 @default.
- W2022705009 hasConceptScore W2022705009C84425145 @default.
- W2022705009 hasConceptScore W2022705009C86803240 @default.
- W2022705009 hasConceptScore W2022705009C95444343 @default.
- W2022705009 hasIssue "1" @default.
- W2022705009 hasLocation W20227050091 @default.
- W2022705009 hasLocation W20227050092 @default.
- W2022705009 hasOpenAccess W2022705009 @default.
- W2022705009 hasPrimaryLocation W20227050091 @default.
- W2022705009 hasRelatedWork W1901412126 @default.
- W2022705009 hasRelatedWork W2020008420 @default.
- W2022705009 hasRelatedWork W2024145976 @default.
- W2022705009 hasRelatedWork W2165320660 @default.
- W2022705009 hasRelatedWork W2405887049 @default.
- W2022705009 hasRelatedWork W2415662583 @default.
- W2022705009 hasRelatedWork W2901583425 @default.
- W2022705009 hasRelatedWork W4283448883 @default.
- W2022705009 hasRelatedWork W4313640443 @default.
- W2022705009 hasRelatedWork W2528453622 @default.
- W2022705009 hasVolume "40" @default.
- W2022705009 isParatext "false" @default.
- W2022705009 isRetracted "false" @default.
- W2022705009 magId "2022705009" @default.
- W2022705009 workType "article" @default.