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- W2022705394 abstract "Sexual dimorphism was observed in nitrite release and IL-1-like molecule production by splenic macrophages of the wall lizard (Hemidactylus flaviviridis), with a higher level in females than in males. Gonadectomy in both males and females resulted in a considerable increase of nitrite and IL-1-like molecule secretion, suggesting that the sex hormones inhibit cytotoxic activity of macrophages. To verify this assumption, dose- and time-related in vitro experiments with male and female sex steroids, dihydrotestosterone (DHT) and 17β-estradiol (E2), respectively, were carried out. E2 and DHT both significantly reduced the nitrite release and IL-1-like molecule production with an increase of dose or duration of treatment." @default.
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- W2022705394 date "2002-02-01" @default.
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- W2022705394 title "In Vitro Effect of Sex Steroids on Cytotoxic Activity of Splenic Macrophages in Wall Lizard (Hemidactylus flaviviridis)" @default.
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- W2022705394 doi "https://doi.org/10.1006/gcen.2001.7744" @default.
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