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• W2022706302 abstract "Objective: To describe the appearances of colorectal liver metastases on diffusion-weighted MRI (DW-MRI) and to compare these appearances with histopathology. Methods: 43 patients with colorectal liver metastases were evaluated using breath-hold DW-MRI (b-values 0, 150 and 500 s mm–2). The b=500 s mm–2 DW-MRI were reviewed consensually for lesion size and appearance by two readers. 18/43 patients underwent surgery allowing radiological–pathological comparison. Tissue sections were reviewed by a pathologist, who classified metastases histologically as cellular, fibrotic, necrotic or mixed. The frequency of DW-MRI findings and histological features were compared using the χ2 test. Results: 84 metastases were found in 43 patients. On b=500 s mm–2 DW-MRI, metastases showed three high signal intensity patterns: rim (55/84), uniform (23/84) and variegate (6/84). Of the 55 metastases showing rim pattern, 54 were >1 cm in diameter (p<0.01, χ2 test). 25/84 metastases were surgically resected. Of these, 11/22 metastases >1 cm in diameter showed rim pattern and demonstrated central necrosis at histopathology (p=0.04, χ2 test). No definite relationship was found between uniform and variegate patterns with histology. Conclusion: Rim high signal intensity was the most common appearance of colorectal liver metastases >1 cm diameter on DW-MRI at b-values of 500 s mm–2, a finding attributable to central necrosis." @default.
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• W2022706302 date "2012-03-01" @default.
• W2022706302 modified "2023-10-14" @default.
• W2022706302 title "Appearances of colorectal hepatic metastases at diffusion-weighted MRI compared with histopathology: initial observations" @default.
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• W2022706302 doi "https://doi.org/10.1259/bjr/11597735" @default.
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