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- W2022707369 abstract "In Gram-negative septic shock, human monocytes synthesize and express on their cytoplasmic membrane tissue factor (TF), a potent activator of the coagulation cascades. The role of TF in triggering disseminated intravascular coagulation (DIC) in these patients appears to be clear. We report the suppressive effect of interleukin-10 (IL-10) on endotoxin-induced TF activity and antigen levels, and on the expression of TF mRNA levels in human monocytes. These results emphasize the potential therapeutic value of this cytokine in septic shock, a condition still associated with a high mortality rate." @default.
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- W2022707369 date "1993-11-08" @default.
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- W2022707369 title "Interleukin-10 inhibits endotoxin-induced tissue factor mRNA production by human monocytes" @default.
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- W2022707369 doi "https://doi.org/10.1016/0014-5793(93)81693-t" @default.
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