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• W2022708149 abstract "W/O/W multiple emulsions composed of medium-chain triglycerides containing insulin with aprotinin, a protease inhibitor, and/or sodium taurocholate, an absorption enhancer, were prepared by a two-step emulsification method at 15°C. Whatever the nature of the substance introduced in the internal aqueous phase, all the emulsions obtained had very similar properties. The yield of insulin encapsulation, measured by HPLC analysis, was approximately 95%. These systems were stable during at least 3 months of storage at 4–6°C. The main release mechanism was a swelling-breakdown phenomenon after dilution of the emulsions under hypo-osmotic conditions. These emulsions were able to protect insulin against enzymatic degradation in vitro." @default.
• W2022708149 created "2016-06-24" @default.
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• W2022708149 date "1997-12-01" @default.
• W2022708149 modified "2023-10-18" @default.
• W2022708149 title "W/O/W multiple emulsions of insulin containing a protease inhibitor and an absorption enhancer: preparation, characterization and determination of stability towards proteases in vitro" @default.
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• W2022708149 doi "https://doi.org/10.1016/s0378-5173(97)00249-4" @default.
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