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- W2022711055 abstract "High-grade osteosarcoma is an aggressive tumor most commonly affecting adolescents. The early age of onset might suggest genetic predisposition; however, the vast majority of the tumors are sporadic. Early onset, most often lack of a predisposing condition or lesion, only infrequent (<2%) prevalence of inheritance, extensive genomic instability, and a wide histological heterogeneity are just few factors to mention that make osteosarcoma difficult to study. Therefore, it is sensible to design and use models representative of the human disease. Here we summarize multiple osteosarcoma models established in vitro and in vivo, comment on their utilities, and highlight newest achievements, such as the use of zebrafish embryos. We conclude that to gain a better understanding of osteosarcoma, simplification of this extremely complex tumor is needed. Therefore, we parse the osteosarcoma problem into parts and propose adequate models to study them each separately. A better understanding of osteosarcoma provides opportunities for discovering and assaying novel effective treatment strategies.Sometimes the model is more interesting than the original diseasePJ Hoedemaeker (1937-2007)." @default.
- W2022711055 created "2016-06-24" @default.
- W2022711055 creator A5000530040 @default.
- W2022711055 creator A5003014435 @default.
- W2022711055 creator A5046390152 @default.
- W2022711055 date "2012-01-01" @default.
- W2022711055 modified "2023-10-13" @default.
- W2022711055 title "Osteosarcoma Models: From Cell Lines to Zebrafish" @default.
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- W2022711055 doi "https://doi.org/10.1155/2012/417271" @default.
- W2022711055 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3329665" @default.
- W2022711055 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22566751" @default.
- W2022711055 hasPublicationYear "2012" @default.
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