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• W2022711906 endingPage "234" @default.
• W2022711906 startingPage "227" @default.
• W2022711906 abstract "The effect of noradrenaline, and mixed ligands to alpha 2-adrenoceptors (alpha 2-AR) and imidazoline receptors (IR), injected intracerebroventricularly (i.c.v.), on sodium intake of sodium depleted rats, was tested against idazoxan, a mixed antagonist ligand to alpha 2-AR and IR. The inhibition of sodium intake induced by noradrenaline (80 nmol) was completely reversed by idazoxan (160 and 320 nmol) injected i.c.v. The inhibition of sodium intake induced by mixed ligands to alpha 2-AR and IR, UK14,304, guanabenz and moxonidine, was antagonized from 50 to 60% by idazoxan i.c.v. The results demonstrate that noradrenaline, a non-ligand for IR, acts on alpha 2-AR inhibiting sodium intake. The possibility that either alpha 2-AR or IR mediate the effect of mixed agonists on sodium intake remains an open question." @default.
• W2022711906 created "2016-06-24" @default.
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• W2022711906 date "1999-08-01" @default.
• W2022711906 modified "2023-10-05" @default.
• W2022711906 title "Noradrenaline and mixed α2-adrenoceptor/imidazoline-receptor ligands: effects on sodium intake" @default.
• W2022711906 cites W1720110446 @default.
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• W2022711906 doi "https://doi.org/10.1016/s0006-8993(99)01695-9" @default.
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