Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022715029> ?p ?o ?g. }
- W2022715029 endingPage "992" @default.
- W2022715029 startingPage "983" @default.
- W2022715029 abstract "The involvement of parkin, PINK1, and DJ1 in mitochondrial dysfunction, oxidative injury, and impaired functioning of the ubiquitin-proteasome system (UPS) has been intensively investigated in light of Parkinson's disease (PD) pathogenesis. However, these pathological mechanisms are not restricted to PD, but are common denominators of various neurodegenerative and neuroinflammatory disorders. It is therefore conceivable that parkin, PINK1, and DJ1 are also linked to the pathogenesis of other neurological diseases, including Alzheimer's disease (AD) and multiple sclerosis (MS). The importance of these proteins in mechanisms underlying neurodegeneration is reflected by the neuroprotective properties of parkin, DJ1, and PINK1 in counteracting oxidative stress and improvement of mitochondrial and UPS functioning. This review provides a concise overview on the cellular functions of the E3 ubiquitin ligase parkin, the mitochondrial kinase PINK1, and the cytoprotective protein DJ1 and their involvement and interplay in processes underlying neurodegeneration in common neurological disorders." @default.
- W2022715029 created "2016-06-24" @default.
- W2022715029 creator A5000135568 @default.
- W2022715029 creator A5001774953 @default.
- W2022715029 creator A5038424391 @default.
- W2022715029 creator A5053722111 @default.
- W2022715029 creator A5089717369 @default.
- W2022715029 date "2012-08-01" @default.
- W2022715029 modified "2023-09-26" @default.
- W2022715029 title "Involvement and interplay of Parkin, PINK1, and DJ1 in neurodegenerative and neuroinflammatory disorders" @default.
- W2022715029 cites W134764564 @default.
- W2022715029 cites W1485984810 @default.
- W2022715029 cites W1493985893 @default.
- W2022715029 cites W1540141415 @default.
- W2022715029 cites W1550876205 @default.
- W2022715029 cites W1877873625 @default.
- W2022715029 cites W1900066504 @default.
- W2022715029 cites W1963967499 @default.
- W2022715029 cites W1967603366 @default.
- W2022715029 cites W1969280474 @default.
- W2022715029 cites W1969789944 @default.
- W2022715029 cites W1973362554 @default.
- W2022715029 cites W1974843588 @default.
- W2022715029 cites W1977743352 @default.
- W2022715029 cites W1981727895 @default.
- W2022715029 cites W1985119207 @default.
- W2022715029 cites W1986413832 @default.
- W2022715029 cites W1987951773 @default.
- W2022715029 cites W1990287702 @default.
- W2022715029 cites W1993479669 @default.
- W2022715029 cites W1994315639 @default.
- W2022715029 cites W1994686763 @default.
- W2022715029 cites W1996197940 @default.
- W2022715029 cites W1998735201 @default.
- W2022715029 cites W2001469824 @default.
- W2022715029 cites W2001531966 @default.
- W2022715029 cites W2002353885 @default.
- W2022715029 cites W2002502410 @default.
- W2022715029 cites W2005764967 @default.
- W2022715029 cites W2007844529 @default.
- W2022715029 cites W2009321462 @default.
- W2022715029 cites W2011083820 @default.
- W2022715029 cites W2011975925 @default.
- W2022715029 cites W2012014117 @default.
- W2022715029 cites W2012112859 @default.
- W2022715029 cites W2012176044 @default.
- W2022715029 cites W2012844038 @default.
- W2022715029 cites W2014143845 @default.
- W2022715029 cites W2014898742 @default.
- W2022715029 cites W2015016389 @default.
- W2022715029 cites W2015932693 @default.
- W2022715029 cites W2021777993 @default.
- W2022715029 cites W2022846785 @default.
- W2022715029 cites W2026648000 @default.
- W2022715029 cites W2026841498 @default.
- W2022715029 cites W2026875466 @default.
- W2022715029 cites W2026946582 @default.
- W2022715029 cites W2030803511 @default.
- W2022715029 cites W2033172620 @default.
- W2022715029 cites W2034286717 @default.
- W2022715029 cites W2035787181 @default.
- W2022715029 cites W2036315090 @default.
- W2022715029 cites W2039474386 @default.
- W2022715029 cites W2039824115 @default.
- W2022715029 cites W2041290559 @default.
- W2022715029 cites W2043326610 @default.
- W2022715029 cites W2046378929 @default.
- W2022715029 cites W2046720254 @default.
- W2022715029 cites W2054556550 @default.
- W2022715029 cites W2055124287 @default.
- W2022715029 cites W2055308573 @default.
- W2022715029 cites W2055538245 @default.
- W2022715029 cites W2057857567 @default.
- W2022715029 cites W2058363482 @default.
- W2022715029 cites W2058653820 @default.
- W2022715029 cites W2065060908 @default.
- W2022715029 cites W2065710720 @default.
- W2022715029 cites W2067354538 @default.
- W2022715029 cites W2068544753 @default.
- W2022715029 cites W2068806054 @default.
- W2022715029 cites W2069479107 @default.
- W2022715029 cites W2070235173 @default.
- W2022715029 cites W2070766926 @default.
- W2022715029 cites W2073449985 @default.
- W2022715029 cites W2076344205 @default.
- W2022715029 cites W2080084871 @default.
- W2022715029 cites W2080853928 @default.
- W2022715029 cites W2085133992 @default.
- W2022715029 cites W2086467109 @default.
- W2022715029 cites W2086733867 @default.
- W2022715029 cites W2086961781 @default.
- W2022715029 cites W2086968984 @default.
- W2022715029 cites W2087277712 @default.
- W2022715029 cites W2089443438 @default.
- W2022715029 cites W2089855415 @default.
- W2022715029 cites W2090777067 @default.
- W2022715029 cites W2091416451 @default.
- W2022715029 cites W2093370096 @default.