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- W2022721848 abstract "Perception of mechanical signals and the biological responses to such stimuli are fundamental properties of load bearing articular cartilage in diarthrodial joints. Chondrocytes utilize mechanical signals to synthesize an extracellular matrix capable of withstanding high loads and shear stresses. Recent studies have shown that chondrocytes undergo changes in shape and volume in a coordinated manner with load induced deformation of the matrix. These matrix changes, together with alterations in hydrostatic pressure, ionic and osmotic composition, interstitial fluid and streaming potentials are, in turn, perceived by chondrocytes. Chondrocyte responses to these stimuli are specific and well coordinated to bring about changes in gene expression, protein synthesis, matrix composition and ultimately biomechanical competence. In this hypothesis paper we propose a chondrocyte mechanoreceptor model incorporating key extracellular matrix macromolecules, integrins, mechanosensitive ion channels, the cytoskeleton and subcellular signal transduction pathways that maintain the chondrocyte phenotype, prevent chondrocyte apoptosis and regulate chondrocyte-specific gene expression." @default.
- W2022721848 created "2016-06-24" @default.
- W2022721848 creator A5013076020 @default.
- W2022721848 creator A5038295064 @default.
- W2022721848 creator A5040009127 @default.
- W2022721848 creator A5058020426 @default.
- W2022721848 date "2002-01-01" @default.
- W2022721848 modified "2023-10-18" @default.
- W2022721848 title "INTEGRINS AND STRETCH ACTIVATED ION CHANNELS; PUTATIVE COMPONENTS OF FUNCTIONAL CELL SURFACE MECHANORECEPTORS IN ARTICULAR CHONDROCYTES" @default.
- W2022721848 cites W1489537396 @default.
- W2022721848 cites W1550235641 @default.
- W2022721848 cites W1640609258 @default.
- W2022721848 cites W1671507194 @default.
- W2022721848 cites W1782148244 @default.
- W2022721848 cites W179053432 @default.
- W2022721848 cites W1831734000 @default.
- W2022721848 cites W1873184289 @default.
- W2022721848 cites W1897804960 @default.
- W2022721848 cites W1915865029 @default.
- W2022721848 cites W1963498248 @default.
- W2022721848 cites W1970889097 @default.
- W2022721848 cites W1973541034 @default.
- W2022721848 cites W1976271632 @default.
- W2022721848 cites W1977426071 @default.
- W2022721848 cites W1978013836 @default.
- W2022721848 cites W1980157244 @default.
- W2022721848 cites W1982372868 @default.
- W2022721848 cites W1982926533 @default.
- W2022721848 cites W1987279985 @default.
- W2022721848 cites W1987568997 @default.
- W2022721848 cites W1988634875 @default.
- W2022721848 cites W1991755030 @default.
- W2022721848 cites W1991987132 @default.
- W2022721848 cites W1993239728 @default.
- W2022721848 cites W1993723750 @default.
- W2022721848 cites W1994277288 @default.
- W2022721848 cites W1994579263 @default.
- W2022721848 cites W2002455853 @default.
- W2022721848 cites W2004866985 @default.
- W2022721848 cites W2005151588 @default.
- W2022721848 cites W2006435282 @default.
- W2022721848 cites W2007915830 @default.
- W2022721848 cites W2009350275 @default.
- W2022721848 cites W2011957687 @default.
- W2022721848 cites W2017627341 @default.
- W2022721848 cites W2018343069 @default.
- W2022721848 cites W2024220496 @default.
- W2022721848 cites W2024817423 @default.
- W2022721848 cites W2032093651 @default.
- W2022721848 cites W2034937637 @default.
- W2022721848 cites W2040127305 @default.
- W2022721848 cites W2040301051 @default.
- W2022721848 cites W2040982919 @default.
- W2022721848 cites W2044028809 @default.
- W2022721848 cites W2044415802 @default.
- W2022721848 cites W2044658581 @default.
- W2022721848 cites W2045277818 @default.
- W2022721848 cites W2048000564 @default.
- W2022721848 cites W2049370978 @default.
- W2022721848 cites W2053518618 @default.
- W2022721848 cites W2054600929 @default.
- W2022721848 cites W2055933712 @default.
- W2022721848 cites W2057047200 @default.
- W2022721848 cites W2058547055 @default.
- W2022721848 cites W2060177572 @default.
- W2022721848 cites W2060209614 @default.
- W2022721848 cites W2062926268 @default.
- W2022721848 cites W2065928015 @default.
- W2022721848 cites W2066358298 @default.
- W2022721848 cites W2067805815 @default.
- W2022721848 cites W2068684319 @default.
- W2022721848 cites W2068738439 @default.
- W2022721848 cites W2069674129 @default.
- W2022721848 cites W2070294327 @default.
- W2022721848 cites W2074910365 @default.
- W2022721848 cites W2075857412 @default.
- W2022721848 cites W2077741258 @default.
- W2022721848 cites W2079573668 @default.
- W2022721848 cites W2083978369 @default.
- W2022721848 cites W2084087342 @default.
- W2022721848 cites W2086914553 @default.
- W2022721848 cites W2087499467 @default.
- W2022721848 cites W2089367768 @default.
- W2022721848 cites W2090117730 @default.
- W2022721848 cites W2091746433 @default.
- W2022721848 cites W2096037817 @default.
- W2022721848 cites W2098588948 @default.
- W2022721848 cites W2101093856 @default.
- W2022721848 cites W2102047286 @default.
- W2022721848 cites W2102753121 @default.
- W2022721848 cites W2104808399 @default.
- W2022721848 cites W2112378103 @default.
- W2022721848 cites W2112520390 @default.
- W2022721848 cites W2113209913 @default.
- W2022721848 cites W2118832725 @default.
- W2022721848 cites W2119452579 @default.
- W2022721848 cites W2126087366 @default.
- W2022721848 cites W2130972481 @default.