FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022722482> ?p ?o ?g. }

• W2022722482 endingPage "52" @default.
• W2022722482 startingPage "39" @default.
• W2022722482 abstract "Several controlled release systems of drugs have been elaborated using a supercritical fluid process. Indeed, recent techniques using a supercritical fluid as a solvent or as an antisolvent are considered to be useful alternatives to produce fine powders. In this preliminary study, the effect of Supercritical Anti Solvent process (SAS) on the release of theophylline from matrices manufactured with hydroxypropylmethylcellulose (HPMC) was investigated. Two grades of HPMC (HPMC E5 and K100) as carriers were considered in order to prepare a sustained delivery system for theophylline which was used as a model drug. The characterization of the drug before and after SAS treatment, and the coprecipitates with carriers, was performed by X-ray Diffraction (XRD) and Differential Scanning Calorimetry (DSC). The dissolution rate of theophylline, theophylline-coprecipitates, and matricial tablets prepared with coprecipitates were determined. The physical characterizations revealed a substantial correspondence of the drug solid state before and after supercritical fluid treatment while drug-polymer interactions in the SAS-coprecipitates were attested. The dissolution studies of the matrices prepared compressing the coprecipitated systems showed that the matrices based on HPMC K100 were able to promote a sustained release of the drug. Further, this advantageous dissolution performance was found to be substantially independent of the pH of the medium. The comparison with the matrices prepared with untreated substances demonstrated that matrices obtained with SAS technique can provide a slower theophylline release rate. A new mathematical model describing the in vitro dissolution kinetics was proposed and successfully tested on these systems." @default.
• W2022722482 created "2016-06-24" @default.
• W2022722482 creator A5004765351 @default.
• W2022722482 creator A5006759438 @default.
• W2022722482 creator A5013539270 @default.
• W2022722482 creator A5015131739 @default.
• W2022722482 creator A5017116406 @default.
• W2022722482 creator A5048817122 @default.
• W2022722482 date "2006-01-01" @default.
• W2022722482 modified "2023-09-26" @default.
• W2022722482 title "Preparation of Theophylline-Hydroxypropylmethylcellulose Matrices Using Supercritical Antisolvent Precipitation: A Preliminary Study" @default.
• W2022722482 cites W1500664364 @default.
• W2022722482 cites W1964097695 @default.
• W2022722482 cites W1964883353 @default.
• W2022722482 cites W1965930827 @default.
• W2022722482 cites W1966561371 @default.
• W2022722482 cites W1970127168 @default.
• W2022722482 cites W1973984178 @default.
• W2022722482 cites W1977861698 @default.
• W2022722482 cites W1981334511 @default.
• W2022722482 cites W1986893363 @default.
• W2022722482 cites W1987359047 @default.
• W2022722482 cites W1989601471 @default.
• W2022722482 cites W1998632644 @default.
• W2022722482 cites W2003480886 @default.
• W2022722482 cites W2004879929 @default.
• W2022722482 cites W2012285245 @default.
• W2022722482 cites W2014259987 @default.
• W2022722482 cites W2016782873 @default.
• W2022722482 cites W2023344799 @default.
• W2022722482 cites W2028316064 @default.
• W2022722482 cites W2030424092 @default.
• W2022722482 cites W2031041986 @default.
• W2022722482 cites W2035934135 @default.
• W2022722482 cites W2036129944 @default.
• W2022722482 cites W2039419728 @default.
• W2022722482 cites W2043275474 @default.
• W2022722482 cites W2059728878 @default.
• W2022722482 cites W2060320802 @default.
• W2022722482 cites W2063063263 @default.
• W2022722482 cites W2067935619 @default.
• W2022722482 cites W2076959999 @default.
• W2022722482 cites W2077300098 @default.
• W2022722482 cites W2079177371 @default.
• W2022722482 cites W2093161248 @default.
• W2022722482 cites W2093332250 @default.
• W2022722482 cites W2116646871 @default.
• W2022722482 cites W2124039519 @default.
• W2022722482 cites W2135817997 @default.
• W2022722482 cites W2137002405 @default.
• W2022722482 cites W2162013328 @default.
• W2022722482 cites W2313758756 @default.
• W2022722482 doi "https://doi.org/10.1080/03639040500388037" @default.
• W2022722482 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16455603" @default.
• W2022722482 hasPublicationYear "2006" @default.
• W2022722482 type Work @default.
• W2022722482 sameAs 2022722482 @default.
• W2022722482 citedByCount "11" @default.
• W2022722482 countsByYear W20227224822015 @default.
• W2022722482 countsByYear W20227224822017 @default.
• W2022722482 countsByYear W20227224822019 @default.
• W2022722482 crossrefType "journal-article" @default.
• W2022722482 hasAuthorship W2022722482A5004765351 @default.
• W2022722482 hasAuthorship W2022722482A5006759438 @default.
• W2022722482 hasAuthorship W2022722482A5013539270 @default.
• W2022722482 hasAuthorship W2022722482A5015131739 @default.
• W2022722482 hasAuthorship W2022722482A5017116406 @default.
• W2022722482 hasAuthorship W2022722482A5048817122 @default.
• W2022722482 hasConcept C107054158 @default.
• W2022722482 hasConcept C118419359 @default.
• W2022722482 hasConcept C121332964 @default.
• W2022722482 hasConcept C127413603 @default.
• W2022722482 hasConcept C14029885 @default.
• W2022722482 hasConcept C153294291 @default.
• W2022722482 hasConcept C155574463 @default.
• W2022722482 hasConcept C178790620 @default.
• W2022722482 hasConcept C185592680 @default.
• W2022722482 hasConcept C192562407 @default.
• W2022722482 hasConcept C2778095195 @default.
• W2022722482 hasConcept C2779820397 @default.
• W2022722482 hasConcept C2780471494 @default.
• W2022722482 hasConcept C2781430271 @default.
• W2022722482 hasConcept C39519442 @default.
• W2022722482 hasConcept C42360764 @default.
• W2022722482 hasConcept C43617362 @default.
• W2022722482 hasConcept C521977710 @default.
• W2022722482 hasConcept C71924100 @default.
• W2022722482 hasConcept C77281830 @default.
• W2022722482 hasConcept C88380143 @default.
• W2022722482 hasConcept C97355855 @default.
• W2022722482 hasConcept C98274493 @default.
• W2022722482 hasConceptScore W2022722482C107054158 @default.
• W2022722482 hasConceptScore W2022722482C118419359 @default.
• W2022722482 hasConceptScore W2022722482C121332964 @default.
• W2022722482 hasConceptScore W2022722482C127413603 @default.
• W2022722482 hasConceptScore W2022722482C14029885 @default.
• W2022722482 hasConceptScore W2022722482C153294291 @default.
• W2022722482 hasConceptScore W2022722482C155574463 @default.

• next