FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022729488> ?p ?o ?g. }

• W2022729488 endingPage "1908" @default.
• W2022729488 startingPage "1897" @default.
• W2022729488 abstract "The organic cation transporters OCT1, 2, and 3 (SLC22A1-3) have been implicated in the elimination of biogenic amines such as histamine. Among them, OCT3 was identified as an uptake-2 transporter, responsible for clearance of histamine. Because increasing evidence suggests the involvement of histamine in cerebral ischemia, we investigated the effects of targeted disruption of organic cation transporter-3 (Oct3) on the severity of ischemic brain damage. Transient focal ischemia for 1 hour was induced by occlusion of the middle cerebral artery (MCA) of homozygous Oct3-deficient mice and their wild-type (Wt) littermates. Although targeted disruption of Oct3 did not affect physiological parameters after MCA occlusion, this disruption significantly increased histamine content in the ischemic cortex and significantly reduced the infarct volume after cerebral ischemia. Furthermore, targeted disruption of Oct3 prevented the reduction of regulatory T-cell proportion after cerebral ischemia while this disruption did not affect Th1 and Th2 cells proportions after ischemia. Since repeated administration of L-histidine (a precursor of histamine) to Wt mice also showed the same effects, our observations suggested that OCT3 is the molecule responsible for clearance of ischemia-induced histamine in the brain and targeted disruption of Oct3 ameliorated ischemic brain damage through an increase in regulatory T cells." @default.
• W2022729488 created "2016-06-24" @default.
• W2022729488 creator A5011598225 @default.
• W2022729488 creator A5025273617 @default.
• W2022729488 creator A5045217576 @default.
• W2022729488 creator A5048218023 @default.
• W2022729488 creator A5050396208 @default.
• W2022729488 creator A5058711314 @default.
• W2022729488 creator A5065800084 @default.
• W2022729488 creator A5071742562 @default.
• W2022729488 creator A5075024731 @default.
• W2022729488 date "2012-06-27" @default.
• W2022729488 modified "2023-10-14" @default.
• W2022729488 title "Targeted Disruption of <i>Organic Cation Transporter 3</i> (<i>Oct3</i>) Ameliorates Ischemic Brain Damage through Modulating Histamine and Regulatory T Cells" @default.
• W2022729488 cites W1593999523 @default.
• W2022729488 cites W1883613417 @default.
• W2022729488 cites W1933153961 @default.
• W2022729488 cites W1959339737 @default.
• W2022729488 cites W1986732006 @default.
• W2022729488 cites W1988086690 @default.
• W2022729488 cites W1995217776 @default.
• W2022729488 cites W2002543308 @default.
• W2022729488 cites W2004015216 @default.
• W2022729488 cites W2004708987 @default.
• W2022729488 cites W2010980945 @default.
• W2022729488 cites W2011158816 @default.
• W2022729488 cites W2012992125 @default.
• W2022729488 cites W2013255276 @default.
• W2022729488 cites W2018773565 @default.
• W2022729488 cites W2020342012 @default.
• W2022729488 cites W2023453290 @default.
• W2022729488 cites W2023749167 @default.
• W2022729488 cites W2025082561 @default.
• W2022729488 cites W2033950872 @default.
• W2022729488 cites W2034050667 @default.
• W2022729488 cites W2036924308 @default.
• W2022729488 cites W2037571461 @default.
• W2022729488 cites W2040896759 @default.
• W2022729488 cites W2044324182 @default.
• W2022729488 cites W2051391932 @default.
• W2022729488 cites W2053182610 @default.
• W2022729488 cites W2062380793 @default.
• W2022729488 cites W2063576193 @default.
• W2022729488 cites W2085487749 @default.
• W2022729488 cites W2092028189 @default.
• W2022729488 cites W2094406397 @default.
• W2022729488 cites W2110566966 @default.
• W2022729488 cites W2114266893 @default.
• W2022729488 cites W2123035658 @default.
• W2022729488 cites W2125864071 @default.
• W2022729488 cites W2151978148 @default.
• W2022729488 cites W2152416112 @default.
• W2022729488 cites W2159103481 @default.
• W2022729488 cites W2159560452 @default.
• W2022729488 cites W2170326611 @default.
• W2022729488 cites W2181210303 @default.
• W2022729488 cites W4244992751 @default.
• W2022729488 doi "https://doi.org/10.1038/jcbfm.2012.92" @default.
• W2022729488 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3463881" @default.
• W2022729488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22739622" @default.
• W2022729488 hasPublicationYear "2012" @default.
• W2022729488 type Work @default.
• W2022729488 sameAs 2022729488 @default.
• W2022729488 citedByCount "20" @default.
• W2022729488 countsByYear W20227294882013 @default.
• W2022729488 countsByYear W20227294882014 @default.
• W2022729488 countsByYear W20227294882015 @default.
• W2022729488 countsByYear W20227294882016 @default.
• W2022729488 countsByYear W20227294882017 @default.
• W2022729488 countsByYear W20227294882018 @default.
• W2022729488 countsByYear W20227294882019 @default.
• W2022729488 countsByYear W20227294882020 @default.
• W2022729488 countsByYear W20227294882021 @default.
• W2022729488 countsByYear W20227294882023 @default.
• W2022729488 crossrefType "journal-article" @default.
• W2022729488 hasAuthorship W2022729488A5011598225 @default.
• W2022729488 hasAuthorship W2022729488A5025273617 @default.
• W2022729488 hasAuthorship W2022729488A5045217576 @default.
• W2022729488 hasAuthorship W2022729488A5048218023 @default.
• W2022729488 hasAuthorship W2022729488A5050396208 @default.
• W2022729488 hasAuthorship W2022729488A5058711314 @default.
• W2022729488 hasAuthorship W2022729488A5065800084 @default.
• W2022729488 hasAuthorship W2022729488A5071742562 @default.
• W2022729488 hasAuthorship W2022729488A5075024731 @default.
• W2022729488 hasBestOaLocation W20227294881 @default.
• W2022729488 hasConcept C104317684 @default.
• W2022729488 hasConcept C1122143 @default.
• W2022729488 hasConcept C126322002 @default.
• W2022729488 hasConcept C149011108 @default.
• W2022729488 hasConcept C185592680 @default.
• W2022729488 hasConcept C189613389 @default.
• W2022729488 hasConcept C2778820722 @default.
• W2022729488 hasConcept C2781041448 @default.
• W2022729488 hasConcept C42219234 @default.
• W2022729488 hasConcept C541997718 @default.
• W2022729488 hasConcept C55493867 @default.
• W2022729488 hasConcept C71924100 @default.
• W2022729488 hasConcept C98274493 @default.

• next