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• W2022730076 abstract "Our previous studies indicated that the endogenous opioid system, particularly the mu-opioid receptor, may be involved in the modulation of methamphetamine (METH)-induced increases in locomotor behavior in mice. This study investigates the effects of naloxonazine, a specific mu-opioid receptor antagonist, on the locomotor behavioral response and phosphorylation pattern of dopamine and cAMP-regulated phosphoprotein of Mr32 (DARPP-32) in striatal dopaminergic transmissions induced by acute administration of METH to mice. Mice were injected with a single dose of naloxonazine (20 mg/kg, i.p.) 60 min before injecting (i.p.) either saline or 1 mg/kg of METH. After a 2-h behavioral test, striatal tissues were collected to determine the protein levels of DARPP-32 and the phosphorylated form of DARPP-32 at the Thr34 and Thr75 sites. Results show that pretreatment with naloxonazine significantly attenuated the acute METH-induced increase in locomotor activity and phosphor-Thr75 DARPP-32 levels. Our data indicate that the mu-opioid receptor blockade reduces the acute METH-induced increase in locomotor activity. This effect may be related to the inhibition of DARPP-32 phosphorylation at the Thr75 site in the striatum of the mice." @default.
• W2022730076 created "2016-06-24" @default.
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• W2022730076 date "2012-07-01" @default.
• W2022730076 modified "2023-09-26" @default.
• W2022730076 title "Naloxonazine, a specific mu-opioid receptor antagonist, attenuates the increment of locomotor activity induced by acute methamphetamine in mice" @default.
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• W2022730076 doi "https://doi.org/10.1016/j.toxlet.2012.04.022" @default.
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