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• W2022731219 endingPage "250" @default.
• W2022731219 startingPage "240" @default.
• W2022731219 abstract "The hippocampus is thought to be involved in a range of cognitive processes, from the ability to acquire new memories, to the ability to learn about spatial relationships. Humans and monkeys with damage to the hippocampus are typically impaired on delayed matching to sample tasks, of which the operant delayed matching to position task (DMTP) is a rat analogue. The reported effects of hippocampal damage on DMTP vary, ranging from delay-dependent deficits to no deficit whatsoever. The present study investigates a novel memory task; the conditional delayed matching/non-matching to position task (CDM/NMTP) in the Skinner box. CDM/NMTP uses the presence of specific stimulus cues to signify whether a particular trial is matching or non-matching in nature. Thus, it incorporates both the task contingencies within one session, and supplements the requirement for remembering the side of the lever in the sample phase with attending to the stimulus and remembering the conditional discrimination for the rule. Rats were trained preoperatively and the effects of bilateral excitotoxic lesions of the hippocampus were examined on postoperative retention of the task. Rats with lesions of the hippocampus incurred a significant impairment on the task that was manifest at all delays intervals. Despite a bias towards matching during training, trials of either type were performed with equivalent accuracy and neither rule was affected differentially by the lesion. This task may prove useful in determining the cognitive roles of a range of brain areas." @default.
• W2022731219 created "2016-06-24" @default.
• W2022731219 creator A5036906108 @default.
• W2022731219 creator A5039606775 @default.
• W2022731219 creator A5069297480 @default.
• W2022731219 date "2006-08-01" @default.
• W2022731219 modified "2023-10-17" @default.
• W2022731219 title "Hippocampal lesions impair performance on a conditional delayed matching and non-matching to position task in the rat" @default.
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• W2022731219 doi "https://doi.org/10.1016/j.bbr.2006.03.042" @default.
• W2022731219 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16697059" @default.
• W2022731219 hasPublicationYear "2006" @default.
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