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- W2022731296 abstract "We have purified, by sequence-specific affinity chromatography, a mitochondrial (mt) matrix protein which binds to the curved DNA located between the replication origin (ori) of the leading strand (ori-H) and the two transcription promoters in the rat mt genome. The protein was characterized by gel electrophoresis as a 67-kDa polypeptide and seems to be involved in the DNA contact on the mt light strand. This protein differs (in the size and location of its DNA-binding site) from other DNA-binding proteins studied so far in animal mt systems. We suggest a role for the 67-kDa protein, assisted by other proteins, in regulating the initiation of leading-strand replication." @default.
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- W2022731296 date "1988-12-01" @default.
- W2022731296 modified "2023-10-16" @default.
- W2022731296 title "Symmetric transcription of the replication origin of rat mitochondrial DNA" @default.
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- W2022731296 doi "https://doi.org/10.1016/0378-1119(88)90156-4" @default.
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