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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022731314> ?p ?o ?g. }

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• W2022731314 abstract "A series of novel chalcone linked imidazolones were prepared and evaluated for their anti-cancer activity against a panel of 53 human tumour cell lines derived from nine different cancer types: leukemia, lung, colon, CNS, melanoma, ovarian, renal, prostate and breast. Some of these hybrids (6, 7 and 8) showed good anti-cancer activity with GI50 values ranging from 1.26 to 13.9 μM. When breast carcinoma cells (MCF-7) were treated with 10 μM concentration of compounds TMAC, CA-4, 6 and 8 cell cycle arrest was observed in G2/M phase. Surprisingly, the increased concentration of the same compound to 30 μM caused accumulation of cells in G0/G1 phase of the cell cycle." @default.
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• W2022731314 date "2010-08-01" @default.
• W2022731314 modified "2023-09-26" @default.
• W2022731314 title "Synthesis and anti-cancer activity of chalcone linked imidazolones" @default.
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• W2022731314 doi "https://doi.org/10.1016/j.bmcl.2010.06.097" @default.
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