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• W2022731325 startingPage "599" @default.
• W2022731325 abstract "We compared the in vivo effects of two organophosphorus (OP) insecticides, chlorpyrifos (CPF) and parathion (PS) on acetylcholine (ACh) synthesis in neonatal, juvenile and adult rats. Basal levels of ACh synthesis were highest in adult rats, intermediate in juveniles and lowest in neonates. Following high (maximum tolerated dosage) subcutaneous exposure to either insecticide, relatively similar degrees of cholinesterase inhibition were noted, but the time to peak reduction varied among the age groups. CPF had no effect on ACh synthesis in neonates, increased synthesis in juveniles and decreased synthesis in adults, but only in the low dose group. PS had more consistent effects on ACh synthesis, decreasing transmitter synthesis in neonates (24 h after dosing) but increasing synthesis in juveniles and adults at both 4 and 24 h after exposure. Selective changes in neurotransmitter synthesis may contribute to differential age-related toxicity of these agents." @default.
• W2022731325 created "2016-06-24" @default.
• W2022731325 creator A5041676888 @default.
• W2022731325 creator A5049056803 @default.
• W2022731325 date "2003-09-01" @default.
• W2022731325 modified "2023-09-23" @default.
• W2022731325 title "Age-related effects of chlorpyrifos and parathion on acetylcholine synthesis in rat striatum" @default.
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• W2022731325 doi "https://doi.org/10.1016/s0892-0362(03)00049-7" @default.
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