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• W2022731881 abstract "More than ten years ago, who would have conceived the possibility that intervention at the level of protein degradation provides the opportunity to influence myocardial structure and function? Proteolysis was considered a process not requiring complex regulatory networks. Then, the role of the ubiquitin–proteasome system (UPS) started to become a novel topic of increasing interest in cardiac research. Nowadays, studies indicate that the UPS can selectively degrade contractile and signaling proteins in the heart, which experimentally affects its morphology and physiology [ 1 Fielitz J. Kim M.S. Shelton J.M. Latif S. Spencer J.A. Glass D.J. et al. Myosin accumulation and striated muscle myopathy result from the loss of muscle RING finger 1 and 3. J Clin Invest. 2007; 117: 2486-2495 Crossref PubMed Scopus (195) Google Scholar , 2 Hedhli N. Lizano P. Hong C. Fritzky L.F. Dhar S.K. Liu H. et al. Proteasome inhibition decreases cardiac remodeling after initiation of pressure overload. Am J Physiol Heart Circ Physiol. 2008; 295: H1385-H1393 Crossref PubMed Scopus (76) Google Scholar , 3 Stansfield W.E. Tang R.H. Moss N.C. Baldwin A.S. Willis M.S. Selzman C.H. Proteasome inhibition promotes regression of left ventricular hypertrophy. Am J Physiol Heart Circ Physiol. 2008; 294: H645-H650 Crossref PubMed Scopus (80) Google Scholar , 4 Baskin K.K. Taegtmeyer H. AMP-activated protein kinase regulates E3 ligases in rodent heart. Circ Res. 2011; 109: 1153-1161 Crossref PubMed Scopus (55) Google Scholar , 5 Li J. Horak K.M. Su H. Sanbe A. Robbins J. Wang X. Enhancement of proteasomal function protects against cardiac proteinopathy and ischemia/reperfusion injury in mice. J Clin Invest. 2011; 121: 3689-3700 Crossref PubMed Scopus (145) Google Scholar ]. This editorial highlights the similarities and differences of UPS regulation in left and right ventricular diseases, including a recent publication in this journal by Fessart et al. [ [6] Fessart D. Martin-Negrier M.L. Claverol S. Thiolat M.L. Crevel H. Toussaint C. et al. Proteomic remodeling of proteasome in right heart failure. J Mol Cell Cardiol. 2013; 66: 41-52https://doi.org/10.1016/j.yjmcc.2013.10.015 Abstract Full Text Full Text PDF PubMed Scopus (20) Google Scholar ]." @default.
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• W2022731881 date "2014-07-01" @default.
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• W2022731881 title "The left and right ventricle in the grip of protein degradation: Similarities and unique patterns in regulation" @default.
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• W2022731881 doi "https://doi.org/10.1016/j.yjmcc.2014.02.016" @default.
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