Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022732422> ?p ?o ?g. }
- W2022732422 endingPage "3860" @default.
- W2022732422 startingPage "3850" @default.
- W2022732422 abstract "The melanocortin 1 receptor gene is a main determinant of human pigmentation, and a melanoma susceptibility gene, because its variants that are strongly associated with red hair color increase melanoma risk. To test experimentally the association between melanocortin 1 receptor genotype and melanoma susceptibility, we compared the responses of primary human melanocyte cultures naturally expressing different melanocortin 1 receptor variants to α-melanocortin and ultraviolet radiation. We found that expression of 2 red hair variants abolished the response to α-melanocortin and its photoprotective effects, evidenced by lack of functional coupling of the receptor, and absence of reduction in ultraviolet radiation-induced hydrogen peroxide generation or enhancement of repair of DNA photoproducts, respectively. These variants had different heterozygous effects on receptor function. Microarray data confirmed the observed differences in responses of melanocytes with functional vs. nonfunctional receptor to α-melanocortin and ultraviolet radiation, and identified DNA repair and antioxidant genes that are modulated by α-melanocortin. Our findings highlight the molecular mechanisms by which the melanocortin 1 receptor genotype controls genomic stability of and the mutagenic effect of ultraviolet radiation on human melanocytes." @default.
- W2022732422 created "2016-06-24" @default.
- W2022732422 creator A5000061916 @default.
- W2022732422 creator A5010983774 @default.
- W2022732422 creator A5012766647 @default.
- W2022732422 creator A5019178531 @default.
- W2022732422 creator A5028712728 @default.
- W2022732422 creator A5036941849 @default.
- W2022732422 creator A5042729967 @default.
- W2022732422 creator A5048313626 @default.
- W2022732422 creator A5062480352 @default.
- W2022732422 creator A5065973944 @default.
- W2022732422 creator A5069657670 @default.
- W2022732422 creator A5071835813 @default.
- W2022732422 creator A5072398720 @default.
- W2022732422 creator A5073173580 @default.
- W2022732422 creator A5074739271 @default.
- W2022732422 creator A5083794647 @default.
- W2022732422 date "2010-06-02" @default.
- W2022732422 modified "2023-10-16" @default.
- W2022732422 title "<i>Melanocortin 1 receptor</i>genotype: an important determinant of the damage response of melanocytes to ultraviolet radiation" @default.
- W2022732422 cites W1524775751 @default.
- W2022732422 cites W1558838236 @default.
- W2022732422 cites W1668019941 @default.
- W2022732422 cites W1969710462 @default.
- W2022732422 cites W1976813357 @default.
- W2022732422 cites W1979420492 @default.
- W2022732422 cites W1979580952 @default.
- W2022732422 cites W1986702270 @default.
- W2022732422 cites W1994661191 @default.
- W2022732422 cites W1995126053 @default.
- W2022732422 cites W2004010426 @default.
- W2022732422 cites W2006985041 @default.
- W2022732422 cites W2011338138 @default.
- W2022732422 cites W2026040423 @default.
- W2022732422 cites W2028304930 @default.
- W2022732422 cites W2034710079 @default.
- W2022732422 cites W2051112657 @default.
- W2022732422 cites W2051718122 @default.
- W2022732422 cites W2054891577 @default.
- W2022732422 cites W2055235209 @default.
- W2022732422 cites W2056184557 @default.
- W2022732422 cites W2058219340 @default.
- W2022732422 cites W2059125805 @default.
- W2022732422 cites W2059304490 @default.
- W2022732422 cites W2060528681 @default.
- W2022732422 cites W2068896977 @default.
- W2022732422 cites W2069423064 @default.
- W2022732422 cites W2073924618 @default.
- W2022732422 cites W2073962547 @default.
- W2022732422 cites W2076712649 @default.
- W2022732422 cites W2089951482 @default.
- W2022732422 cites W2101121350 @default.
- W2022732422 cites W2115022580 @default.
- W2022732422 cites W2123300899 @default.
- W2022732422 cites W2123439746 @default.
- W2022732422 cites W2124896191 @default.
- W2022732422 cites W2138982513 @default.
- W2022732422 cites W2158117735 @default.
- W2022732422 cites W2158496331 @default.
- W2022732422 cites W2158637523 @default.
- W2022732422 cites W2159812536 @default.
- W2022732422 cites W2162658371 @default.
- W2022732422 cites W2167028317 @default.
- W2022732422 cites W2183553772 @default.
- W2022732422 cites W4234254898 @default.
- W2022732422 doi "https://doi.org/10.1096/fj.10-158485" @default.
- W2022732422 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3229421" @default.
- W2022732422 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20519635" @default.
- W2022732422 hasPublicationYear "2010" @default.
- W2022732422 type Work @default.
- W2022732422 sameAs 2022732422 @default.
- W2022732422 citedByCount "114" @default.
- W2022732422 countsByYear W20227324222012 @default.
- W2022732422 countsByYear W20227324222013 @default.
- W2022732422 countsByYear W20227324222014 @default.
- W2022732422 countsByYear W20227324222015 @default.
- W2022732422 countsByYear W20227324222016 @default.
- W2022732422 countsByYear W20227324222017 @default.
- W2022732422 countsByYear W20227324222018 @default.
- W2022732422 countsByYear W20227324222019 @default.
- W2022732422 countsByYear W20227324222020 @default.
- W2022732422 countsByYear W20227324222021 @default.
- W2022732422 countsByYear W20227324222022 @default.
- W2022732422 countsByYear W20227324222023 @default.
- W2022732422 crossrefType "journal-article" @default.
- W2022732422 hasAuthorship W2022732422A5000061916 @default.
- W2022732422 hasAuthorship W2022732422A5010983774 @default.
- W2022732422 hasAuthorship W2022732422A5012766647 @default.
- W2022732422 hasAuthorship W2022732422A5019178531 @default.
- W2022732422 hasAuthorship W2022732422A5028712728 @default.
- W2022732422 hasAuthorship W2022732422A5036941849 @default.
- W2022732422 hasAuthorship W2022732422A5042729967 @default.
- W2022732422 hasAuthorship W2022732422A5048313626 @default.
- W2022732422 hasAuthorship W2022732422A5062480352 @default.
- W2022732422 hasAuthorship W2022732422A5065973944 @default.
- W2022732422 hasAuthorship W2022732422A5069657670 @default.
- W2022732422 hasAuthorship W2022732422A5071835813 @default.