Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022732661> ?p ?o ?g. }
- W2022732661 endingPage "1043" @default.
- W2022732661 startingPage "1034" @default.
- W2022732661 abstract "Family II chitin synthases (CS), including classes IV and V enzymes, share conserved catalytic domains flanked by transmembrane regions. Here we addressed the characterization of Family II fungal CSs by heterologous expression in Saccharomyces cerevisiae. Full-length CSs from classes V or IV were not functional when expressed in S. cerevisiae and accumulated in different intracellular compartments. However, the exchange between different class IV, but not of class V, CHS domains resulted in functional proteins both in vivo and in vitro. The different domains afford the chimeric proteins distinct intracellular behaviours, ranging from endoplasmic reticulum retention to reduced endocytic turnover at the plasma membrane. These results allow a role in chitin synthesis to be assigned to all class IV enzymes, but they also highlight the involvement of the intracellular globular domain of these CSs, not only in enzymatic activity but also in the regulation of their intracellular turnover." @default.
- W2022732661 created "2016-06-24" @default.
- W2022732661 creator A5005424128 @default.
- W2022732661 creator A5032091177 @default.
- W2022732661 creator A5048930087 @default.
- W2022732661 creator A5052794074 @default.
- W2022732661 date "2010-12-01" @default.
- W2022732661 modified "2023-10-16" @default.
- W2022732661 title "Amino acid divergence between the CHS domain contributes to the different intracellular behaviour of Family II fungal chitin synthases in Saccharomyces cerevisiae" @default.
- W2022732661 cites W1509299150 @default.
- W2022732661 cites W1538462311 @default.
- W2022732661 cites W1543250028 @default.
- W2022732661 cites W1962676038 @default.
- W2022732661 cites W1967779180 @default.
- W2022732661 cites W1975593876 @default.
- W2022732661 cites W1997335986 @default.
- W2022732661 cites W2000456081 @default.
- W2022732661 cites W2009053439 @default.
- W2022732661 cites W2016334729 @default.
- W2022732661 cites W2021838894 @default.
- W2022732661 cites W2022070087 @default.
- W2022732661 cites W2031647687 @default.
- W2022732661 cites W2038204439 @default.
- W2022732661 cites W2046045366 @default.
- W2022732661 cites W2047091642 @default.
- W2022732661 cites W2047406588 @default.
- W2022732661 cites W2057684829 @default.
- W2022732661 cites W2076535984 @default.
- W2022732661 cites W2093862878 @default.
- W2022732661 cites W2098408225 @default.
- W2022732661 cites W2098973691 @default.
- W2022732661 cites W2099267345 @default.
- W2022732661 cites W2104734640 @default.
- W2022732661 cites W2105753898 @default.
- W2022732661 cites W2107183837 @default.
- W2022732661 cites W2111644062 @default.
- W2022732661 cites W2115987023 @default.
- W2022732661 cites W2119910427 @default.
- W2022732661 cites W2122536523 @default.
- W2022732661 cites W2126334121 @default.
- W2022732661 cites W2127149001 @default.
- W2022732661 cites W2137053568 @default.
- W2022732661 cites W2138910991 @default.
- W2022732661 cites W2139584811 @default.
- W2022732661 cites W2146333367 @default.
- W2022732661 cites W2147984476 @default.
- W2022732661 cites W2149590947 @default.
- W2022732661 cites W2152995920 @default.
- W2022732661 cites W2155687518 @default.
- W2022732661 cites W2158164361 @default.
- W2022732661 cites W2170149951 @default.
- W2022732661 cites W3022297326 @default.
- W2022732661 cites W4232501930 @default.
- W2022732661 doi "https://doi.org/10.1016/j.fgb.2010.08.013" @default.
- W2022732661 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20817000" @default.
- W2022732661 hasPublicationYear "2010" @default.
- W2022732661 type Work @default.
- W2022732661 sameAs 2022732661 @default.
- W2022732661 citedByCount "7" @default.
- W2022732661 countsByYear W20227326612012 @default.
- W2022732661 countsByYear W20227326612016 @default.
- W2022732661 countsByYear W20227326612018 @default.
- W2022732661 crossrefType "journal-article" @default.
- W2022732661 hasAuthorship W2022732661A5005424128 @default.
- W2022732661 hasAuthorship W2022732661A5032091177 @default.
- W2022732661 hasAuthorship W2022732661A5048930087 @default.
- W2022732661 hasAuthorship W2022732661A5052794074 @default.
- W2022732661 hasConcept C104317684 @default.
- W2022732661 hasConcept C108305142 @default.
- W2022732661 hasConcept C158617107 @default.
- W2022732661 hasConcept C170493617 @default.
- W2022732661 hasConcept C181199279 @default.
- W2022732661 hasConcept C2777576037 @default.
- W2022732661 hasConcept C2779222958 @default.
- W2022732661 hasConcept C2779732960 @default.
- W2022732661 hasConcept C2781088250 @default.
- W2022732661 hasConcept C28005876 @default.
- W2022732661 hasConcept C40767141 @default.
- W2022732661 hasConcept C55493867 @default.
- W2022732661 hasConcept C79747257 @default.
- W2022732661 hasConcept C79879829 @default.
- W2022732661 hasConcept C86803240 @default.
- W2022732661 hasConcept C95444343 @default.
- W2022732661 hasConceptScore W2022732661C104317684 @default.
- W2022732661 hasConceptScore W2022732661C108305142 @default.
- W2022732661 hasConceptScore W2022732661C158617107 @default.
- W2022732661 hasConceptScore W2022732661C170493617 @default.
- W2022732661 hasConceptScore W2022732661C181199279 @default.
- W2022732661 hasConceptScore W2022732661C2777576037 @default.
- W2022732661 hasConceptScore W2022732661C2779222958 @default.
- W2022732661 hasConceptScore W2022732661C2779732960 @default.
- W2022732661 hasConceptScore W2022732661C2781088250 @default.
- W2022732661 hasConceptScore W2022732661C28005876 @default.
- W2022732661 hasConceptScore W2022732661C40767141 @default.
- W2022732661 hasConceptScore W2022732661C55493867 @default.
- W2022732661 hasConceptScore W2022732661C79747257 @default.
- W2022732661 hasConceptScore W2022732661C79879829 @default.
- W2022732661 hasConceptScore W2022732661C86803240 @default.