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- W2022734550 abstract "We examined the role of retinoid-related orphan receptor (ROR)β, a member of the nuclear receptor family of transcription factors, in retinal neurogenesis. In situ hybridization studies showed that RORβ is expressed in retinal progenitor cells in the embryonic rat retina. Further studies demonstrated that RORβ colocalizes with Chx10, a transcription factor thought to influence retinal progenitor proliferation (Burmeister, M., Novak, J., Liang, M-Y., Basu, S., Ploder, L., Hawes, N.L. Vidgen, D., Hoover, F., Goldman, D., Kalnins, V.I., Roderick, T.H., Taylor, B.A., Hankin, M.H. and McInnes, R.R., 1996. Ocular retardation mouse caused by Chx10 homeobox null allele: impaired retinal progenitor proliferation and bipolar cell differentiation. Nat. Genet. 12, 376–383). Northern analysis reveals that RORβ expression is dramatically decreased in the ocular retardationJ mutant, which possesses a defect in the Chx10 gene. Overexpression of RORβ in retinal progenitors by biolistic transfection results in an increase in the number of large cell clones. These data support a role for RORβ in regulating retinal progenitor proliferation, possibly via the Chx10 gene." @default.
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- W2022734550 date "1998-09-01" @default.
- W2022734550 modified "2023-09-30" @default.
- W2022734550 title "The nuclear receptor transcription factor, retinoid-related orphan receptor β, regulates retinal progenitor proliferation" @default.
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- W2022734550 doi "https://doi.org/10.1016/s0925-4773(98)00135-x" @default.
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