FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022736043> ?p ?o ?g. }

• W2022736043 endingPage "334" @default.
• W2022736043 startingPage "327" @default.
• W2022736043 abstract "B-CLL cells are arrested in G0/early G1 phase of the cell cycle and are characterized by a marked hyporesponsiveness towards a variety of polyclonal B cell activators. We have previously demonstrated that costimulation with CpG-ODN and IL-2 can overcome this proliferative defect. Cyclin D3 is the principal D-type cyclin which mediates G1 progression in normal B cells, but in B-CLL cells both cyclin D2 and cyclin D3, were strongly upregulated upon stimulation. Both cyclins were associated with cdk4 but not with cdk6, which is the catalytic partner of D-type cyclins in normal B cells. Moreover, immune complexes consisting of cyclin D2 and cdk4 or cyclin D3 and cdk4 were both functional and phosphorylated the RB protein in vitro. The cell cycle inhibitor p27 plays a pivotal role in cell cycle progression of B lymphocytes and has been shown to be overexpressed in B-CLL cells. P27 was rapidly downregulated in B-CLL cells even when stimulated with a non-CpG-ODN or IL-2 alone, while only moderate regulation could be observed in normal B cells. Taken together, our findings demonstrate that regulation of early cell cycle progression differs between B-CLL cells and normal B cells. These findings do not only contribute to the understanding of B-CLL pathophysiology, but might ultimately lead to the identification of new therapeutic targets." @default.
• W2022736043 created "2016-06-24" @default.
• W2022736043 creator A5005474411 @default.
• W2022736043 creator A5029656956 @default.
• W2022736043 creator A5039868942 @default.
• W2022736043 creator A5066200247 @default.
• W2022736043 creator A5070282254 @default.
• W2022736043 creator A5081028472 @default.
• W2022736043 creator A5088789978 @default.
• W2022736043 date "2002-03-01" @default.
• W2022736043 modified "2023-10-15" @default.
• W2022736043 title "Cell cycle progression of chronic lymphocytic leukemia cells is controlled by cyclin D2, cyclin D3, cyclin-dependent kinase (cdk) 4 and the cdk inhibitor p27" @default.
• W2022736043 cites W1496464057 @default.
• W2022736043 cites W1499230593 @default.
• W2022736043 cites W1524792851 @default.
• W2022736043 cites W153676044 @default.
• W2022736043 cites W1553376453 @default.
• W2022736043 cites W1568808961 @default.
• W2022736043 cites W180295822 @default.
• W2022736043 cites W1876313598 @default.
• W2022736043 cites W1956007715 @default.
• W2022736043 cites W1969617808 @default.
• W2022736043 cites W1971254046 @default.
• W2022736043 cites W1980720313 @default.
• W2022736043 cites W1986264978 @default.
• W2022736043 cites W1986635401 @default.
• W2022736043 cites W2004726009 @default.
• W2022736043 cites W2013691481 @default.
• W2022736043 cites W2013785496 @default.
• W2022736043 cites W2021457628 @default.
• W2022736043 cites W2022329296 @default.
• W2022736043 cites W2029080338 @default.
• W2022736043 cites W2033989981 @default.
• W2022736043 cites W2047110135 @default.
• W2022736043 cites W2048721919 @default.
• W2022736043 cites W2066191439 @default.
• W2022736043 cites W2079187701 @default.
• W2022736043 cites W2083173501 @default.
• W2022736043 cites W2091403769 @default.
• W2022736043 cites W2098675621 @default.
• W2022736043 cites W2101666778 @default.
• W2022736043 cites W2101904615 @default.
• W2022736043 cites W2109384031 @default.
• W2022736043 cites W2116382475 @default.
• W2022736043 cites W2123206370 @default.
• W2022736043 cites W2161762726 @default.
• W2022736043 cites W2221262359 @default.
• W2022736043 cites W2268103037 @default.
• W2022736043 cites W2321522269 @default.
• W2022736043 cites W2343131342 @default.
• W2022736043 cites W2343398839 @default.
• W2022736043 cites W2415890524 @default.
• W2022736043 cites W2417543242 @default.
• W2022736043 cites W26559748 @default.
• W2022736043 cites W4243098077 @default.
• W2022736043 cites W4251555887 @default.
• W2022736043 cites W51210568 @default.
• W2022736043 doi "https://doi.org/10.1038/sj.leu.2402389" @default.
• W2022736043 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11896535" @default.
• W2022736043 hasPublicationYear "2002" @default.
• W2022736043 type Work @default.
• W2022736043 sameAs 2022736043 @default.
• W2022736043 citedByCount "94" @default.
• W2022736043 countsByYear W20227360432012 @default.
• W2022736043 countsByYear W20227360432013 @default.
• W2022736043 countsByYear W20227360432014 @default.
• W2022736043 countsByYear W20227360432015 @default.
• W2022736043 countsByYear W20227360432016 @default.
• W2022736043 countsByYear W20227360432017 @default.
• W2022736043 countsByYear W20227360432018 @default.
• W2022736043 countsByYear W20227360432019 @default.
• W2022736043 countsByYear W20227360432020 @default.
• W2022736043 countsByYear W20227360432021 @default.
• W2022736043 countsByYear W20227360432022 @default.
• W2022736043 countsByYear W20227360432023 @default.
• W2022736043 crossrefType "journal-article" @default.
• W2022736043 hasAuthorship W2022736043A5005474411 @default.
• W2022736043 hasAuthorship W2022736043A5029656956 @default.
• W2022736043 hasAuthorship W2022736043A5039868942 @default.
• W2022736043 hasAuthorship W2022736043A5066200247 @default.
• W2022736043 hasAuthorship W2022736043A5070282254 @default.
• W2022736043 hasAuthorship W2022736043A5081028472 @default.
• W2022736043 hasAuthorship W2022736043A5088789978 @default.
• W2022736043 hasBestOaLocation W20227360431 @default.
• W2022736043 hasConcept C11882975 @default.
• W2022736043 hasConcept C120089663 @default.
• W2022736043 hasConcept C124320809 @default.
• W2022736043 hasConcept C1491633281 @default.
• W2022736043 hasConcept C16438837 @default.
• W2022736043 hasConcept C199649820 @default.
• W2022736043 hasConcept C2778298596 @default.
• W2022736043 hasConcept C2780733254 @default.
• W2022736043 hasConcept C2781403221 @default.
• W2022736043 hasConcept C28179978 @default.
• W2022736043 hasConcept C29537977 @default.
• W2022736043 hasConcept C502942594 @default.
• W2022736043 hasConcept C55493867 @default.
• W2022736043 hasConcept C86803240 @default.

• next