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- W2022740047 abstract "An attempt was made to integrate the biochemical, cellular, and animal pharmacology of certain antineoplastic agents in order to design a model chemotherapeutic regimen that was based on scientific rationale. The agents that were chosen for this investigation were 5-fluorodeoxyuridine (FUdR), 5-bromodeoxyuridine (BUdR), and β-deoxythioguanosine (TGdR) because the biochemical interactions between these antimetabolites suggested that this drug combination would be synergistic with respect to its antineoplastic activity. The combination FUdR plus BUdR was found to be synergistic with respect to its in vitro cytotoxicity against tumor cells and its in vivo activity in mice with L1210 leukemia. When FUdR, BUdR, and TGdR were used in combination its in vitro cytotoxicity was synergistic. This 3 drug combination was not synergistic in vivo, but did produce a very potent antileukemic effect in the mice. Although more data are needed before it can be determined if this model drug combination has any future clinical application, this overall approach shows that it is possible to integrate the pharmacological data of antineoplastic agents and if used with some of the conventional antileukemic agents may possibly lead to the rational design of some very effective drug combinations for the treatment of acute leukemia." @default.
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- W2022740047 date "1977-01-01" @default.
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- W2022740047 title "Integration of biochemical, cellular, and animal pharmacology of antineoplastic agents to design new model drug combinations for treatment of acute leukemia" @default.
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- W2022740047 doi "https://doi.org/10.1016/0145-2126(77)90051-0" @default.
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