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• W2022740116 abstract "Ischemic stroke (IS) outcome predictors include clinical features, biochemical parameters and some risk factors. The relations between two main players in the ischemic brain, MMPs and HMGB1, were estimated in the plasma of ischemic stroke patients stratified according to the Glasgow Outcome Scale and the Oxfordshire Community Stroke Project classification. IS patients exhibited higher plasma concentration of MMP-9 and the inflammatory cytokine HMGB1 compared with healthy controls. A full-blown correlation between MMP-9 activation and increased plasma MMP-9 concentration was observed in case of IS patients. A similar activity of MMP-2 and MMP-12 was characteristic of healthy volunteers and IS patients. In patients with ischemic stroke increased plasma levels of MMP-9 and HMGB1 are associated with a poor functional outcome and are significantly correlated with each other (P = 0.0054). We suggest that diagnostic benefits will be obtained if plasma HMGB1 levels are measured for IS patients in addition to MMP-9. • We made the first study of the relation between MMP-9 and HMGB1 following acute IS. • A strong correlation was detected between MMP-9 and HMGB1 and with a poor outcome. • The activated MMP-9 can be considered as an effective marker for negative outcome. • The strong correlation between plasma MMP-9 quantity and activity was noted. • Measurement of plasma HMGB1 in addition to MMP-9 benefits IS diagnostics." @default.
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• W2022740116 date "2014-09-01" @default.
• W2022740116 modified "2023-09-26" @default.
• W2022740116 title "Correlation between MMP-9 and extracellular cytokine HMGB1 in prediction of human ischemic stroke outcome" @default.
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• W2022740116 doi "https://doi.org/10.1016/j.bbadis.2014.04.031" @default.
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