Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022740911> ?p ?o ?g. }
- W2022740911 endingPage "74" @default.
- W2022740911 startingPage "63" @default.
- W2022740911 abstract "The virulence antigen (LcrV) of pathogenic yersiniae “silences” macrophages against stimulation with the TLR2-agonist zymosan A in a CD14/TLR2-dependent fashion via IL-10 induction. This pathogenically important “silencing” resembles TLR tolerance phenomena; in these, pre-exposure to a primary tolerizing TLR-agonist renders macrophages unresponsive to stimulation with a secondary challenging TLR-agonist which may involve either the same (TLR homotolerance) or a different TLR (TLR heterotolerance) as the primary TLR-agonist. Here, we show that rLcrV induces TLR homo- and heterotolerance against TLR2- or TLR4-agonists both in human and murine macrophages, respectively. The underlying mechanism of LcrV-induced tolerance is most likely not due to changes in TLR2- or TLR4 expression, but involves LcrV-mediated IL-10 production, since LcrV-induced TLR homo- and heterotolerance is highly impaired in IL-10−/− macrophages. Moreover, the involvement of IL-10 in TLR tolerance induction seems to be a more general phenomenon as shown by experiments using different TLR-agonists in IL-10−/− macrophages. Since LcrV acts as a secreted protein upon macrophages without requiring direct cell contact, as shown in transwell assays, we propose that yersiniae exploit IL-10-involving TLR tolerance mechanisms by the virulence factor LcrV." @default.
- W2022740911 created "2016-06-24" @default.
- W2022740911 creator A5014158855 @default.
- W2022740911 creator A5069456081 @default.
- W2022740911 creator A5073716097 @default.
- W2022740911 creator A5082570606 @default.
- W2022740911 creator A5089365864 @default.
- W2022740911 date "2004-09-01" @default.
- W2022740911 modified "2023-10-18" @default.
- W2022740911 title "Yersinia V antigen induces both TLR homo- and heterotolerance in an IL-10-involving manner" @default.
- W2022740911 cites W1480290224 @default.
- W2022740911 cites W1489852543 @default.
- W2022740911 cites W1525024972 @default.
- W2022740911 cites W1533876739 @default.
- W2022740911 cites W1536351090 @default.
- W2022740911 cites W1596708757 @default.
- W2022740911 cites W1607116834 @default.
- W2022740911 cites W1627009127 @default.
- W2022740911 cites W1807430256 @default.
- W2022740911 cites W1855676723 @default.
- W2022740911 cites W1866781827 @default.
- W2022740911 cites W1901875036 @default.
- W2022740911 cites W1912774014 @default.
- W2022740911 cites W1945510071 @default.
- W2022740911 cites W1947904991 @default.
- W2022740911 cites W1953329867 @default.
- W2022740911 cites W1970047013 @default.
- W2022740911 cites W1971533272 @default.
- W2022740911 cites W1976873557 @default.
- W2022740911 cites W1983898382 @default.
- W2022740911 cites W1992024672 @default.
- W2022740911 cites W1996239444 @default.
- W2022740911 cites W1997329172 @default.
- W2022740911 cites W2005473844 @default.
- W2022740911 cites W2009286881 @default.
- W2022740911 cites W2011417491 @default.
- W2022740911 cites W2020889689 @default.
- W2022740911 cites W2027830444 @default.
- W2022740911 cites W2032253758 @default.
- W2022740911 cites W2035217892 @default.
- W2022740911 cites W2073723461 @default.
- W2022740911 cites W2086390353 @default.
- W2022740911 cites W2092591554 @default.
- W2022740911 cites W2095710623 @default.
- W2022740911 cites W2100719344 @default.
- W2022740911 cites W2101363646 @default.
- W2022740911 cites W2104942758 @default.
- W2022740911 cites W2106687873 @default.
- W2022740911 cites W2108596257 @default.
- W2022740911 cites W2112974611 @default.
- W2022740911 cites W2114092160 @default.
- W2022740911 cites W2115216196 @default.
- W2022740911 cites W2118050533 @default.
- W2022740911 cites W2120412245 @default.
- W2022740911 cites W2122708604 @default.
- W2022740911 cites W2123795063 @default.
- W2022740911 cites W2129280927 @default.
- W2022740911 cites W2129319176 @default.
- W2022740911 cites W2132091434 @default.
- W2022740911 cites W2136057472 @default.
- W2022740911 cites W2141560710 @default.
- W2022740911 cites W2142549613 @default.
- W2022740911 cites W2145912774 @default.
- W2022740911 cites W2149150753 @default.
- W2022740911 cites W2149269977 @default.
- W2022740911 cites W2150929880 @default.
- W2022740911 cites W2154862758 @default.
- W2022740911 cites W2161458737 @default.
- W2022740911 cites W2162671357 @default.
- W2022740911 cites W2167715503 @default.
- W2022740911 cites W2168105659 @default.
- W2022740911 cites W2319903483 @default.
- W2022740911 cites W2472648115 @default.
- W2022740911 cites W4248219898 @default.
- W2022740911 doi "https://doi.org/10.1016/j.cellimm.2004.12.003" @default.
- W2022740911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15919371" @default.
- W2022740911 hasPublicationYear "2004" @default.
- W2022740911 type Work @default.
- W2022740911 sameAs 2022740911 @default.
- W2022740911 citedByCount "19" @default.
- W2022740911 countsByYear W20227409112012 @default.
- W2022740911 countsByYear W20227409112013 @default.
- W2022740911 countsByYear W20227409112014 @default.
- W2022740911 countsByYear W20227409112016 @default.
- W2022740911 countsByYear W20227409112017 @default.
- W2022740911 countsByYear W20227409112020 @default.
- W2022740911 crossrefType "journal-article" @default.
- W2022740911 hasAuthorship W2022740911A5014158855 @default.
- W2022740911 hasAuthorship W2022740911A5069456081 @default.
- W2022740911 hasAuthorship W2022740911A5073716097 @default.
- W2022740911 hasAuthorship W2022740911A5082570606 @default.
- W2022740911 hasAuthorship W2022740911A5089365864 @default.
- W2022740911 hasConcept C202751555 @default.
- W2022740911 hasConcept C203014093 @default.
- W2022740911 hasConcept C2776070231 @default.
- W2022740911 hasConcept C2776255393 @default.
- W2022740911 hasConcept C2778870864 @default.
- W2022740911 hasConcept C2781236682 @default.