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- W2022742910 endingPage "990" @default.
- W2022742910 startingPage "977" @default.
- W2022742910 abstract "The two oxysterol receptors, 'liver X receptors (LXRs)' LXRα and LXRβ, are amongst the emerging newer drug targets within the nuclear receptor family and targeting LXRs represents novel strategies needed for prevention and treatment of diseases where current therapeutics is inadequate.This review discusses the current understanding of LXR biology with an emphasis on the molecular aspects of LXR signalling establishing their potential as drug targets. Recent advances of their transcriptional mechanisms in inflammatory pathways and their physiological roles in inflammation and immunity are described.The new discoveries of LXR-regulated inflammatory pathways have ignited new promises for LXRs as drug targets. The broad physiological roles of LXRs involve a high risk of unwanted side effects. Recent insights into LXR biology of the brain indicate a highly important role in neuronal development and a clinical trial testing an LXR agonist reported adverse neurological side effects. This suggests that drug development must focus on limiting the range of LXR signalling - possibly achieved through subtype, tissue specific, promoter specific or pathway specific activation of LXRs where a successful candidate drug must be carefully studied for its effect in the central nervous system." @default.
- W2022742910 created "2016-06-24" @default.
- W2022742910 creator A5026622036 @default.
- W2022742910 creator A5048735833 @default.
- W2022742910 creator A5085801141 @default.
- W2022742910 date "2013-06-06" @default.
- W2022742910 modified "2023-09-26" @default.
- W2022742910 title "Targeting liver X receptors in inflammation" @default.
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