FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022743211> ?p ?o ?g. }

• W2022743211 endingPage "e1728" @default.
• W2022743211 startingPage "e1728" @default.
• W2022743211 abstract "Trypanosoma brucei rhodesiense (Tbr) and T. b. gambiense (Tbg), causative agents of Human African Trypanosomiasis (sleeping sickness) in Africa, have evolved alternative mechanisms of resisting the activity of trypanosome lytic factors (TLFs), components of innate immunity in human serum that protect against infection by other African trypanosomes. In Tbr, lytic activity is suppressed by the Tbr-specific serum-resistance associated (SRA) protein. The mechanism in Tbg is less well understood but has been hypothesized to involve altered activity and expression of haptoglobin haemoglobin receptor (HpHbR). HpHbR has been shown to facilitate internalization of TLF-1 in T.b. brucei (Tbb), a member of the T. brucei species complex that is susceptible to human serum. By evaluating the genetic variability of HpHbR in a comprehensive geographical and taxonomic context, we show that a single substitution that replaces leucine with serine at position 210 is conserved in the most widespread form of Tbg (Tbg group 1) and not found in related taxa, which are either human serum susceptible (Tbb) or known to resist lysis via an alternative mechanism (Tbr and Tbg group 2). We hypothesize that this single substitution contributes to reduced uptake of TLF and thus may play a key role in conferring serum resistance to Tbg group 1. In contrast, similarity in HpHbR sequence among isolates of Tbg group 2 and Tbb/Tbr provides further evidence that human serum resistance in Tbg group 2 is likely independent of HpHbR function." @default.
• W2022743211 created "2016-06-24" @default.
• W2022743211 creator A5013431632 @default.
• W2022743211 creator A5046372749 @default.
• W2022743211 creator A5047272159 @default.
• W2022743211 creator A5056035116 @default.
• W2022743211 creator A5057947463 @default.
• W2022743211 creator A5067154980 @default.
• W2022743211 creator A5070399707 @default.
• W2022743211 creator A5088582272 @default.
• W2022743211 date "2012-07-10" @default.
• W2022743211 modified "2023-09-27" @default.
• W2022743211 title "Trypanosoma brucei gambiense Group 1 Is Distinguished by a Unique Amino Acid Substitution in the HpHb Receptor Implicated in Human Serum Resistance" @default.
• W2022743211 cites W1586563633 @default.
• W2022743211 cites W1593278459 @default.
• W2022743211 cites W1603934734 @default.
• W2022743211 cites W1964708040 @default.
• W2022743211 cites W1972899475 @default.
• W2022743211 cites W1977687273 @default.
• W2022743211 cites W1982443613 @default.
• W2022743211 cites W1997589622 @default.
• W2022743211 cites W1999030993 @default.
• W2022743211 cites W2007167713 @default.
• W2022743211 cites W2016069807 @default.
• W2022743211 cites W2020914412 @default.
• W2022743211 cites W2049170930 @default.
• W2022743211 cites W2051650406 @default.
• W2022743211 cites W2074486083 @default.
• W2022743211 cites W2078937868 @default.
• W2022743211 cites W2105658033 @default.
• W2022743211 cites W2110755408 @default.
• W2022743211 cites W2164418313 @default.
• W2022743211 cites W4250713400 @default.
• W2022743211 doi "https://doi.org/10.1371/journal.pntd.0001728" @default.
• W2022743211 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3393672" @default.
• W2022743211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22802982" @default.
• W2022743211 hasPublicationYear "2012" @default.
• W2022743211 type Work @default.
• W2022743211 sameAs 2022743211 @default.
• W2022743211 citedByCount "35" @default.
• W2022743211 countsByYear W20227432112012 @default.
• W2022743211 countsByYear W20227432112013 @default.
• W2022743211 countsByYear W20227432112014 @default.
• W2022743211 countsByYear W20227432112015 @default.
• W2022743211 countsByYear W20227432112016 @default.
• W2022743211 countsByYear W20227432112017 @default.
• W2022743211 countsByYear W20227432112018 @default.
• W2022743211 countsByYear W20227432112019 @default.
• W2022743211 countsByYear W20227432112020 @default.
• W2022743211 countsByYear W20227432112022 @default.
• W2022743211 countsByYear W20227432112023 @default.
• W2022743211 crossrefType "journal-article" @default.
• W2022743211 hasAuthorship W2022743211A5013431632 @default.
• W2022743211 hasAuthorship W2022743211A5046372749 @default.
• W2022743211 hasAuthorship W2022743211A5047272159 @default.
• W2022743211 hasAuthorship W2022743211A5056035116 @default.
• W2022743211 hasAuthorship W2022743211A5057947463 @default.
• W2022743211 hasAuthorship W2022743211A5067154980 @default.
• W2022743211 hasAuthorship W2022743211A5070399707 @default.
• W2022743211 hasAuthorship W2022743211A5088582272 @default.
• W2022743211 hasBestOaLocation W20227432111 @default.
• W2022743211 hasConcept C104317684 @default.
• W2022743211 hasConcept C151730666 @default.
• W2022743211 hasConcept C159047783 @default.
• W2022743211 hasConcept C182615771 @default.
• W2022743211 hasConcept C203014093 @default.
• W2022743211 hasConcept C2522874641 @default.
• W2022743211 hasConcept C2778143080 @default.
• W2022743211 hasConcept C2778792689 @default.
• W2022743211 hasConcept C2779343474 @default.
• W2022743211 hasConcept C2779502636 @default.
• W2022743211 hasConcept C54355233 @default.
• W2022743211 hasConcept C86803240 @default.
• W2022743211 hasConceptScore W2022743211C104317684 @default.
• W2022743211 hasConceptScore W2022743211C151730666 @default.
• W2022743211 hasConceptScore W2022743211C159047783 @default.
• W2022743211 hasConceptScore W2022743211C182615771 @default.
• W2022743211 hasConceptScore W2022743211C203014093 @default.
• W2022743211 hasConceptScore W2022743211C2522874641 @default.
• W2022743211 hasConceptScore W2022743211C2778143080 @default.
• W2022743211 hasConceptScore W2022743211C2778792689 @default.
• W2022743211 hasConceptScore W2022743211C2779343474 @default.
• W2022743211 hasConceptScore W2022743211C2779502636 @default.
• W2022743211 hasConceptScore W2022743211C54355233 @default.
• W2022743211 hasConceptScore W2022743211C86803240 @default.
• W2022743211 hasIssue "7" @default.
• W2022743211 hasLocation W20227432111 @default.
• W2022743211 hasLocation W20227432112 @default.
• W2022743211 hasLocation W20227432113 @default.
• W2022743211 hasLocation W20227432114 @default.
• W2022743211 hasLocation W20227432115 @default.
• W2022743211 hasOpenAccess W2022743211 @default.
• W2022743211 hasPrimaryLocation W20227432111 @default.
• W2022743211 hasRelatedWork W1932076390 @default.
• W2022743211 hasRelatedWork W1987542375 @default.
• W2022743211 hasRelatedWork W2022077055 @default.
• W2022743211 hasRelatedWork W2051779138 @default.
• W2022743211 hasRelatedWork W2091546582 @default.

• next