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- W2022743869 abstract "The purpose of this study is to investigate the role of PI3K-Akt signaling in prostate cancer cell growth and androgen receptor (AR)-mediated gene expression. Androgen-dependent LNCaP cells and their androgen-independent counterpart, LNCaP-AI cells, were used. We found that PI3K-Akt signaling is elevated in LNCaP-AI cells compared to that in LNCaP cells and is involved in androgen-independent growth. More importantly, PI3K-Akt signaling enhances AR activity and is involved in the induction of AR target genes, such as p21WAF/CIP, a gene with anti-apoptosis activity and associated with androgen-independent growth in human prostate cancer. A receptor tyrosine kinase inhibitor also inhibits the PI3K-Akt signaling and compromises AR activity and cell growth. These findings suggest that the PI3K-Akt cell growth survival pathway and its downstream-regulated gene, p21WAF/CIP, are targets for developing novel therapies against prostate cancer, especially those androgen-independent diseases." @default.
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- W2022743869 date "2006-01-01" @default.
- W2022743869 modified "2023-09-25" @default.
- W2022743869 title "PI3K-Akt signaling is involved in the regulation of p21WAF/CIP expression and androgen-independent growth in prostate cancer cells" @default.
- W2022743869 doi "https://doi.org/10.3892/ijo.28.1.245" @default.
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