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- W2022744061 abstract "Six rabbits were exposed for 4 months (5 days/week, 6 h/day) and 6 rabbits for 8 months to approx. 0.1 mg/m3 of metallic nickel dust (U.S. threshold limit value (TLV) 1 mg/m3). Another 8 rabbits were exposed for 4–6 weeks (5 days/week, 6 h/day) to 0.3 mg/m3 (as Ni) of nickel chloride (U.S. TLV 0.1 mg/mn3). After exposure lungs were lavaged. Concentration of lysozyme in the lavage fluid was estimated with the lyso-plate technique (agar plates with heat-killed Micrococcus lysodeikticus after macrophages had been removed. All 3 exposed groups had markedly lower concentrations of lysozyme than corresponding controls. Mean values in controls and exposed rabbits were: for 4 months metallic nickel dust exposure 2.3 and ≤ 0.04 μg/ml; for 8 months metallic nickel dust exposure 14. and ≤ 0.5 μg/ml; and for nickel chloride exposure 1.9 and ≤ 0.4 μg/ml." @default.
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- W2022744061 date "1981-01-01" @default.
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- W2022744061 title "Decreased level of lysozyme in rabbit lung lavage fluid after inhalation of low nickel concentrations" @default.
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- W2022744061 doi "https://doi.org/10.1016/0300-483x(81)90029-9" @default.
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