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- W2022750736 abstract "Most solid tumors contain aneuploid cells, indicating that the mitotic checkpoint is permissive to the proliferation of chromosomally aberrant cells. However, mutated or altered expression of mitotic checkpoint genes accounts for a minor proportion of human tumors. We describe a Drosophila melanogaster tumorigenesis model derived from knocking down spindle assembly checkpoint (SAC) genes and preventing apoptosis in wing imaginal discs. Bub3-deficient tumors that were also deficient in apoptosis displayed neoplastic growth, chromosomal aneuploidy, and high proliferative potential after transplantation into adult flies. Inducing aneuploidy by knocking down CENP-E and preventing apoptosis does not induce tumorigenesis, indicating that aneuploidy is not sufficient for hyperplasia. In this system, the aneuploidy caused by a deficient SAC is not driving tumorigenesis because preventing Bub3 from binding to the kinetochore does not cause hyperproliferation. Our data suggest that Bub3 has a nonkinetochore-dependent function that is consistent with its role as a tumor suppressor." @default.
- W2022750736 created "2016-06-24" @default.
- W2022750736 creator A5052681947 @default.
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- W2022750736 date "2013-04-22" @default.
- W2022750736 modified "2023-10-15" @default.
- W2022750736 title "A tumor suppressor role of the Bub3 spindle checkpoint protein after apoptosis inhibition" @default.
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- W2022750736 doi "https://doi.org/10.1083/jcb.201210018" @default.
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