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- W2022751166 abstract "The effect of the infusion of 2-hydroxyestrone (125 micrograms/h for 8 h) on plasma PRL levels was investigated before and 64 h after the administration of 1 mg estradiol benzoate in five patients with PRL-secreting pituitary adenomas. There was no effect on the circulating PRL levels measured hourly for 8 h during both episodes of 2-hydroxyestrone infusion, but plasma LH and FSH levels were suppressed. Infusion of 2-hydroxyestrone in two hyperprolactinemic patients with craniopharyngeomas also did not change the circulating PRL levels. We conclude that: 1) 2-Hydroxyestrone does not suppress PRL levels in patients with prolactinomas. This is not caused by the low estrogenic state of these patients, because 2-hydroxyestrone remained ineffective after the administration of estradiol. 2-Hydroxyestrone was also not able to suppress the estradiol-induced stimulation of PRL release. 2) 2-Hydroxyestrone does not diminish PRL levels in patients with suprasellar tumors and hyperprolactinemia. Therefore, infusion of 2-hydroxyestrone cannot be used in the differential diagnosis of hypothalamic and tumoral hyperprolactinemia." @default.
- W2022751166 created "2016-06-24" @default.
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- W2022751166 date "1983-02-01" @default.
- W2022751166 modified "2023-09-24" @default.
- W2022751166 title "Absence of a Suppressive Effect of 2-Hydroxyestrone on Hyperprolactinemia in Patients with Prolactinomas before and after Estradiol Administration*" @default.
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- W2022751166 doi "https://doi.org/10.1210/jcem-56-2-230" @default.
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