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• W2022751526 abstract "Abstract Background The Ras-related GTPase, Rheb, regulates the growth of animal cells. Genetic and biochemical tests place Rheb upstream of the target of rapamycin (TOR) protein kinase, and downstream of the tuberous sclerosis complex (TSC1/TSC2) and the insulin-signaling pathway. TOR activity is regulated by nutritional cues, suggesting that Rheb might either control, or respond to, nutrient availability. Results We show that Rheb and TOR do not promote the import of glucose, bulk amino acids, or arginine in Drosophila S2 cells, but that both gene products are important regulators of ribosome biogenesis, protein synthesis, and cell size. S2 cell size, protein synthesis, and glucose import were largely insensitive to manipulations of insulin signaling components, suggesting that cellular energy levels and TOR activity can be maintained through insulin/PI3K-independent mechanisms in S2 cell culture. In vivo in Drosophila larvae, however, we found that insulin signaling can regulate protein synthesis, and thus may affect TOR activity. Conclusion Rheb-TOR signaling controls S2 cell growth by promoting ribosome production and protein synthesis, but apparently not by direct effects on the import of amino acids or glucose. The effect of insulin signaling upon TOR activity varies according to cellular type and context." @default.
• W2022751526 created "2016-06-24" @default.
• W2022751526 creator A5025597290 @default.
• W2022751526 creator A5063978936 @default.
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• W2022751526 creator A5069048670 @default.
• W2022751526 date "2007-03-19" @default.
• W2022751526 modified "2023-10-18" @default.
• W2022751526 title "Rheb-TOR signaling promotes protein synthesis, but not glucose or amino acid import, in Drosophila" @default.
• W2022751526 cites W151110305 @default.
• W2022751526 cites W1534104940 @default.
• W2022751526 cites W1536070820 @default.
• W2022751526 cites W1574585714 @default.
• W2022751526 cites W1877343178 @default.
• W2022751526 cites W1939431494 @default.
• W2022751526 cites W1969442037 @default.
• W2022751526 cites W1970212288 @default.
• W2022751526 cites W1971357899 @default.
• W2022751526 cites W1977747566 @default.
• W2022751526 cites W1978625554 @default.
• W2022751526 cites W1979612739 @default.
• W2022751526 cites W1983247384 @default.
• W2022751526 cites W1984674883 @default.
• W2022751526 cites W1987942547 @default.
• W2022751526 cites W1989964807 @default.
• W2022751526 cites W1992257057 @default.
• W2022751526 cites W1994817218 @default.
• W2022751526 cites W1999789975 @default.
• W2022751526 cites W2001568034 @default.
• W2022751526 cites W2006559495 @default.
• W2022751526 cites W2008239768 @default.
• W2022751526 cites W2009607823 @default.
• W2022751526 cites W2010763118 @default.
• W2022751526 cites W2011055466 @default.
• W2022751526 cites W2011282245 @default.
• W2022751526 cites W2012288142 @default.
• W2022751526 cites W2016394900 @default.
• W2022751526 cites W2018938558 @default.
• W2022751526 cites W2020726089 @default.
• W2022751526 cites W2023819606 @default.
• W2022751526 cites W2027424090 @default.
• W2022751526 cites W2029577022 @default.
• W2022751526 cites W2030606525 @default.
• W2022751526 cites W2036040491 @default.
• W2022751526 cites W2038916704 @default.
• W2022751526 cites W2042360183 @default.
• W2022751526 cites W2044249604 @default.
• W2022751526 cites W2051718741 @default.
• W2022751526 cites W2052578642 @default.
• W2022751526 cites W2054591128 @default.
• W2022751526 cites W2054998824 @default.
• W2022751526 cites W2055248589 @default.
• W2022751526 cites W2056137479 @default.
• W2022751526 cites W2067673948 @default.
• W2022751526 cites W2068442488 @default.
• W2022751526 cites W2073898739 @default.
• W2022751526 cites W2075092037 @default.
• W2022751526 cites W2076684078 @default.
• W2022751526 cites W2081221632 @default.
• W2022751526 cites W2081526354 @default.
• W2022751526 cites W2082853003 @default.
• W2022751526 cites W2083919459 @default.
• W2022751526 cites W2086589626 @default.
• W2022751526 cites W2088782756 @default.
• W2022751526 cites W2089632625 @default.
• W2022751526 cites W2089731973 @default.
• W2022751526 cites W2094941511 @default.
• W2022751526 cites W2107900138 @default.
• W2022751526 cites W2109263914 @default.
• W2022751526 cites W2114990983 @default.
• W2022751526 cites W2117257231 @default.
• W2022751526 cites W2120106989 @default.
• W2022751526 cites W2120934046 @default.
• W2022751526 cites W2121018790 @default.
• W2022751526 cites W2126536047 @default.
• W2022751526 cites W2129585918 @default.
• W2022751526 cites W2131844826 @default.
• W2022751526 cites W2134138119 @default.
• W2022751526 cites W2143339101 @default.
• W2022751526 cites W2143579943 @default.
• W2022751526 cites W2152289580 @default.
• W2022751526 cites W2153552867 @default.
• W2022751526 cites W2155138686 @default.
• W2022751526 cites W2155726348 @default.
• W2022751526 cites W2161422385 @default.
• W2022751526 cites W2161594264 @default.
• W2022751526 cites W2163382569 @default.
• W2022751526 cites W2164462432 @default.
• W2022751526 cites W2166613767 @default.
• W2022751526 cites W2170704593 @default.
• W2022751526 cites W2329391383 @default.
• W2022751526 cites W4238567307 @default.
• W2022751526 doi "https://doi.org/10.1186/1741-7007-5-10" @default.
• W2022751526 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1847425" @default.
• W2022751526 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17371599" @default.
• W2022751526 hasPublicationYear "2007" @default.
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