Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022752602> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2022752602 endingPage "584" @default.
- W2022752602 startingPage "582" @default.
- W2022752602 abstract "Amplification of the MYCN gene is found in a large proportion of neuroblastomas and is associated with a poor prognosis.To investigate the effect of ectopic MycN expression on the susceptibility of neuroblastoma cells to cytotoxic drugs, we used a human neuroblastoma cell line with tetracycline-controlled expression of MycN.Neither conditional expression of MycN alone nor low drug concentrations induced apoptosis. However, MycN and cytotoxic drugs cooperated to induce cell death. Apoptosis triggered by MycN and doxorubicin was mediated by cleavage of caspases and involved activation of the CD95 system. MycN overexpression and cytotoxic drugs also synergized to induce p53 and Bax protein expression and to trigger mitochondrial permeability transition and cytochrome c release.In that amplification of MYCN is considered an adverse prognostic factor, these findings suggest that dysfunctions in apoptosis pathways may be a mechanism by which MycN-induced apoptosis of neuroblastoma cells is inhibited." @default.
- W2022752602 created "2016-06-24" @default.
- W2022752602 creator A5002676793 @default.
- W2022752602 creator A5051618572 @default.
- W2022752602 creator A5075397312 @default.
- W2022752602 creator A5080913590 @default.
- W2022752602 date "2000-01-01" @default.
- W2022752602 modified "2023-09-26" @default.
- W2022752602 title "MycN sensitizes neuroblastoma cells for drug-triggered apoptosis" @default.
- W2022752602 cites W1509850974 @default.
- W2022752602 cites W1550247880 @default.
- W2022752602 cites W1959376412 @default.
- W2022752602 cites W1971967721 @default.
- W2022752602 cites W1977499961 @default.
- W2022752602 cites W1983386156 @default.
- W2022752602 cites W1990522751 @default.
- W2022752602 cites W2022199544 @default.
- W2022752602 cites W2042044981 @default.
- W2022752602 cites W2060683243 @default.
- W2022752602 cites W2093515639 @default.
- W2022752602 cites W2132625535 @default.
- W2022752602 cites W2171416485 @default.
- W2022752602 cites W2321776541 @default.
- W2022752602 cites W2326266120 @default.
- W2022752602 cites W2329408473 @default.
- W2022752602 doi "https://doi.org/10.1002/1096-911x(20001201)35:6<582::aid-mpo19>3.0.co;2-2" @default.
- W2022752602 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11107122" @default.
- W2022752602 hasPublicationYear "2000" @default.
- W2022752602 type Work @default.
- W2022752602 sameAs 2022752602 @default.
- W2022752602 citedByCount "23" @default.
- W2022752602 countsByYear W20227526022012 @default.
- W2022752602 countsByYear W20227526022013 @default.
- W2022752602 countsByYear W20227526022018 @default.
- W2022752602 countsByYear W20227526022019 @default.
- W2022752602 countsByYear W20227526022021 @default.
- W2022752602 countsByYear W20227526022022 @default.
- W2022752602 crossrefType "journal-article" @default.
- W2022752602 hasAuthorship W2022752602A5002676793 @default.
- W2022752602 hasAuthorship W2022752602A5051618572 @default.
- W2022752602 hasAuthorship W2022752602A5075397312 @default.
- W2022752602 hasAuthorship W2022752602A5080913590 @default.
- W2022752602 hasConcept C126322002 @default.
- W2022752602 hasConcept C154317977 @default.
- W2022752602 hasConcept C190283241 @default.
- W2022752602 hasConcept C202751555 @default.
- W2022752602 hasConcept C2776694085 @default.
- W2022752602 hasConcept C2776715637 @default.
- W2022752602 hasConcept C2781303535 @default.
- W2022752602 hasConcept C31573885 @default.
- W2022752602 hasConcept C502942594 @default.
- W2022752602 hasConcept C54355233 @default.
- W2022752602 hasConcept C71924100 @default.
- W2022752602 hasConcept C81885089 @default.
- W2022752602 hasConcept C86803240 @default.
- W2022752602 hasConcept C97037327 @default.
- W2022752602 hasConceptScore W2022752602C126322002 @default.
- W2022752602 hasConceptScore W2022752602C154317977 @default.
- W2022752602 hasConceptScore W2022752602C190283241 @default.
- W2022752602 hasConceptScore W2022752602C202751555 @default.
- W2022752602 hasConceptScore W2022752602C2776694085 @default.
- W2022752602 hasConceptScore W2022752602C2776715637 @default.
- W2022752602 hasConceptScore W2022752602C2781303535 @default.
- W2022752602 hasConceptScore W2022752602C31573885 @default.
- W2022752602 hasConceptScore W2022752602C502942594 @default.
- W2022752602 hasConceptScore W2022752602C54355233 @default.
- W2022752602 hasConceptScore W2022752602C71924100 @default.
- W2022752602 hasConceptScore W2022752602C81885089 @default.
- W2022752602 hasConceptScore W2022752602C86803240 @default.
- W2022752602 hasConceptScore W2022752602C97037327 @default.
- W2022752602 hasIssue "6" @default.
- W2022752602 hasLocation W20227526021 @default.
- W2022752602 hasLocation W20227526022 @default.
- W2022752602 hasOpenAccess W2022752602 @default.
- W2022752602 hasPrimaryLocation W20227526021 @default.
- W2022752602 hasRelatedWork W1853758218 @default.
- W2022752602 hasRelatedWork W1984512710 @default.
- W2022752602 hasRelatedWork W1998121995 @default.
- W2022752602 hasRelatedWork W2008479527 @default.
- W2022752602 hasRelatedWork W2022573986 @default.
- W2022752602 hasRelatedWork W2060963594 @default.
- W2022752602 hasRelatedWork W2160782587 @default.
- W2022752602 hasRelatedWork W2337834220 @default.
- W2022752602 hasRelatedWork W2348210391 @default.
- W2022752602 hasRelatedWork W118413780 @default.
- W2022752602 hasVolume "35" @default.
- W2022752602 isParatext "false" @default.
- W2022752602 isRetracted "false" @default.
- W2022752602 magId "2022752602" @default.
- W2022752602 workType "article" @default.