FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022752955> ?p ?o ?g. }

• W2022752955 endingPage "1216" @default.
• W2022752955 startingPage "1211" @default.
• W2022752955 abstract "Abstract Although a minor population of paroxysmal nocturnal hemoglobinuria (PNH)–type blood cells is often detected in patients with aplastic anemia (AA) and refractory anemia (RA), the significance of such cells in the pathophysiology of bone marrow (BM) failure remains obscure. We therefore examined clonality in peripheral blood granulocytes from 118 female patients with AA or myelodysplastic syndrome using the X chromosome inactivation pattern. Clonality, defined as a clonal population accounting for 35% or more of total granulocytes, was confirmed in 22 of 68 (32.4%) AA patients, in 13 of 44 (29.5%) RA patients, in all 4 RA with excess blasts (RAEB) patients, and in 4 patients with PNH. When the frequency of patients with granulocyte clonality was compared with respect to the presence of increased PNH-type cells, the frequency was significantly lower in AA patients with (PNH+; 21.2%) than without (PNH–; 42.9%) increased numbers of PNH-type cells (P = .049). Clonality was absent in granulocytes from the 15 PNH+ RA patients but present in 13 of 29 (44.8%) PNH– RA patients (P = .0013). The absence of clonality in AA and RA patients before treatment was strongly associated with positive response to immunosuppressive therapy (without clonality, 74.4%; with clonality, 33.3%; P = .0031) in all patients as well as in PNH+ patients (without clonality, 96.2%; with clonality, 66.6%, P = .026). These results suggest that AA and RA with a minor population of PNH-type cells are benign types of BM failure with immune pathophysiology that have little relationship to clonal disorders such as RAEB or acute myeloid leukemia." @default.
• W2022752955 created "2016-06-24" @default.
• W2022752955 creator A5010271694 @default.
• W2022752955 creator A5028349481 @default.
• W2022752955 creator A5042147058 @default.
• W2022752955 creator A5043874175 @default.
• W2022752955 creator A5054423210 @default.
• W2022752955 creator A5090120974 @default.
• W2022752955 date "2003-08-15" @default.
• W2022752955 modified "2023-10-02" @default.
• W2022752955 title "Polyclonal hematopoiesis maintained in patients with bone marrow failure harboring a minor population of paroxysmal nocturnal hemoglobinuria–type cells" @default.
• W2022752955 cites W1512073250 @default.
• W2022752955 cites W1597452190 @default.
• W2022752955 cites W1966072600 @default.
• W2022752955 cites W1973311214 @default.
• W2022752955 cites W1979653263 @default.
• W2022752955 cites W1982763716 @default.
• W2022752955 cites W1989373596 @default.
• W2022752955 cites W2004617067 @default.
• W2022752955 cites W2011059381 @default.
• W2022752955 cites W2021789061 @default.
• W2022752955 cites W2028835250 @default.
• W2022752955 cites W2033383261 @default.
• W2022752955 cites W2033594330 @default.
• W2022752955 cites W2037777034 @default.
• W2022752955 cites W2039007181 @default.
• W2022752955 cites W2041465634 @default.
• W2022752955 cites W2047065795 @default.
• W2022752955 cites W2049077945 @default.
• W2022752955 cites W2049145072 @default.
• W2022752955 cites W2072367160 @default.
• W2022752955 cites W2072791659 @default.
• W2022752955 cites W2090222271 @default.
• W2022752955 cites W2103557265 @default.
• W2022752955 cites W2118605967 @default.
• W2022752955 cites W2136722781 @default.
• W2022752955 cites W2159900811 @default.
• W2022752955 cites W2168744717 @default.
• W2022752955 cites W2240670295 @default.
• W2022752955 cites W2337101530 @default.
• W2022752955 cites W2345467492 @default.
• W2022752955 cites W2435819325 @default.
• W2022752955 cites W3112311983 @default.
• W2022752955 cites W38113815 @default.
• W2022752955 cites W4241658885 @default.
• W2022752955 cites W4242239767 @default.
• W2022752955 cites W4246970818 @default.
• W2022752955 cites W4247972768 @default.
• W2022752955 doi "https://doi.org/10.1182/blood-2002-12-3706" @default.
• W2022752955 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12676778" @default.
• W2022752955 hasPublicationYear "2003" @default.
• W2022752955 type Work @default.
• W2022752955 sameAs 2022752955 @default.
• W2022752955 citedByCount "51" @default.
• W2022752955 countsByYear W20227529552012 @default.
• W2022752955 countsByYear W20227529552013 @default.
• W2022752955 countsByYear W20227529552014 @default.
• W2022752955 countsByYear W20227529552015 @default.
• W2022752955 countsByYear W20227529552016 @default.
• W2022752955 countsByYear W20227529552017 @default.
• W2022752955 countsByYear W20227529552018 @default.
• W2022752955 countsByYear W20227529552019 @default.
• W2022752955 countsByYear W20227529552020 @default.
• W2022752955 countsByYear W20227529552021 @default.
• W2022752955 countsByYear W20227529552022 @default.
• W2022752955 crossrefType "journal-article" @default.
• W2022752955 hasAuthorship W2022752955A5010271694 @default.
• W2022752955 hasAuthorship W2022752955A5028349481 @default.
• W2022752955 hasAuthorship W2022752955A5042147058 @default.
• W2022752955 hasAuthorship W2022752955A5043874175 @default.
• W2022752955 hasAuthorship W2022752955A5054423210 @default.
• W2022752955 hasAuthorship W2022752955A5090120974 @default.
• W2022752955 hasBestOaLocation W20227529551 @default.
• W2022752955 hasConcept C10162356 @default.
• W2022752955 hasConcept C109159458 @default.
• W2022752955 hasConcept C126322002 @default.
• W2022752955 hasConcept C203014093 @default.
• W2022752955 hasConcept C2777346216 @default.
• W2022752955 hasConcept C2778248108 @default.
• W2022752955 hasConcept C2778639011 @default.
• W2022752955 hasConcept C2780007613 @default.
• W2022752955 hasConcept C2780525284 @default.
• W2022752955 hasConcept C2780817109 @default.
• W2022752955 hasConcept C2781440808 @default.
• W2022752955 hasConcept C28328180 @default.
• W2022752955 hasConcept C2908647359 @default.
• W2022752955 hasConcept C54355233 @default.
• W2022752955 hasConcept C71924100 @default.
• W2022752955 hasConcept C86803240 @default.
• W2022752955 hasConcept C99454951 @default.
• W2022752955 hasConceptScore W2022752955C10162356 @default.
• W2022752955 hasConceptScore W2022752955C109159458 @default.
• W2022752955 hasConceptScore W2022752955C126322002 @default.
• W2022752955 hasConceptScore W2022752955C203014093 @default.
• W2022752955 hasConceptScore W2022752955C2777346216 @default.
• W2022752955 hasConceptScore W2022752955C2778248108 @default.
• W2022752955 hasConceptScore W2022752955C2778639011 @default.
• W2022752955 hasConceptScore W2022752955C2780007613 @default.

• next