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- W2022752968 abstract "1. Evoked electrical activity was observed in slices from guinea-pig olfactory cortex maintained in vitro. This evoked activity was studied in saline solutions containing various concentrations of Ca2+ and Mg2+. 2. The evoked potentials recorded from the surface of the prepiriform cortex comprised a negative wave (N-wave) of about 10–15 msec duration upon which a variable number of short duration positive notches were superimposed. The N-wave was identified as a population excitatory post-synaptic potential (EPSP) of the olfactory cortex neurones and the positive notches were identified with synchronous discharge of cortical neurones. 3. The relation between the EPSP amplitude and saline Ca2+ concentration was sigmoid. The N-wave amplitude (EPSP) was proportional to [Ca2+]on. When saline Ca2+ was between 0·4 and 1 m M n averaged 2·5 (range 1·5–4·3). 4. The EPSP amplitude was reduced by increasing saline [Mg2+]. High Mg2+ salines (about 10 m M) abolished the EPSP. 5. Both Ca2+ and Mg2+ in high concentrations depressed the positive notches. 6. Salines containing little or no Ca2+ and Mg2+ caused the preparation to show signs of hyperexcitability. Under these conditions the evoked potentials were very variable and unstable. ‘Ca2+-free’ salines caused a reversible loss of excitability. 7. The results indicated that Ca2+ and Mg2+ had antagonistic effects on the release of the transmitter substance(s). Increased Ca2+ concentrations increased the output of transmitter, increased Mg2+ concentrations reduced the output of transmitter. Both Ca2+ and Mg2+ in increasing concentration increased the threshold for action potential generation." @default.
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- W2022752968 title "Calcium, magnesium and the electrical activity of guinea-pig olfactory cortex<i>in vitro</i>" @default.
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- W2022752968 doi "https://doi.org/10.1113/jphysiol.1970.sp009294" @default.
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