Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022753652> ?p ?o ?g. }
- W2022753652 endingPage "1201" @default.
- W2022753652 startingPage "1192" @default.
- W2022753652 abstract "There is evidence of prefrontal cortex (PFC)-dependent cognitive deficits, such as working memory impairment, during the normal aging process in humans and animals. Although working memory function and the PFC dopaminergic system are thought to be closely related, the relationship between them in aged subjects remains unclear. The present study was aimed to clarify the involvement of PFC dopaminergic activity in age-related working memory impairment. For this purpose, we examined working memory in young (3-month-old) and aged (24-month-old) rats, using the T-maze delayed alternation task. As a result, delayed alternation performance was impaired in aged rats compared to young rats, indicating age-related working memory impairment. In addition, aged rats showed reduced dopaminergic transmission in the prelimbic cortical region of the PFC, concomitant with attenuated tyrosine hydroxylase activity in the PFC, but not in the ventral tegmental area and substantia nigra, which was evaluated immunohistochemically and enzymatically. Moreover, age-related working memory impairment was improved by direct stimulation of the prelimbic cortical region of the PFC with 10 or 30 ng, but not 100 ng, of a D1 receptor agonist, SKF 81297, indicating that the SKF 81297 response was an inverted U pattern. The maximum SKF 81297 response (30 ng) was abolished by a D1 receptor antagonist, SCH 23390. Thus, age-related working memory impairment was through reduced PFC dopaminergic transmission caused by decreased dopamine synthesis in the prefrontal termination region, but not at the site where the projections originate. This finding provides direct evidence showing the involvement of dopaminergic dysfunction in the development of PFC cognitive deficits during the normal aging process and would help to understand the aging physiology and pathology of the brain." @default.
- W2022753652 created "2016-06-24" @default.
- W2022753652 creator A5026750915 @default.
- W2022753652 creator A5036005998 @default.
- W2022753652 creator A5038209011 @default.
- W2022753652 creator A5048608152 @default.
- W2022753652 creator A5062670282 @default.
- W2022753652 date "2009-09-01" @default.
- W2022753652 modified "2023-10-16" @default.
- W2022753652 title "Age-related spatial working memory impairment is caused by prefrontal cortical dopaminergic dysfunction in rats" @default.
- W2022753652 cites W143960986 @default.
- W2022753652 cites W1550411069 @default.
- W2022753652 cites W1659384861 @default.
- W2022753652 cites W1886000739 @default.
- W2022753652 cites W1948611034 @default.
- W2022753652 cites W1963525184 @default.
- W2022753652 cites W1967402003 @default.
- W2022753652 cites W1967696997 @default.
- W2022753652 cites W1980125796 @default.
- W2022753652 cites W1981207011 @default.
- W2022753652 cites W1982166376 @default.
- W2022753652 cites W1986349982 @default.
- W2022753652 cites W1987445320 @default.
- W2022753652 cites W1993355744 @default.
- W2022753652 cites W1994357188 @default.
- W2022753652 cites W1994487396 @default.
- W2022753652 cites W1999489033 @default.
- W2022753652 cites W2000035870 @default.
- W2022753652 cites W2000247756 @default.
- W2022753652 cites W2002132239 @default.
- W2022753652 cites W2009615669 @default.
- W2022753652 cites W2010162749 @default.
- W2022753652 cites W2010351278 @default.
- W2022753652 cites W2014305382 @default.
- W2022753652 cites W2018897037 @default.
- W2022753652 cites W2022702575 @default.
- W2022753652 cites W2024391265 @default.
- W2022753652 cites W2026788979 @default.
- W2022753652 cites W2026900054 @default.
- W2022753652 cites W2029809954 @default.
- W2022753652 cites W2032361563 @default.
- W2022753652 cites W2032576926 @default.
- W2022753652 cites W2035970476 @default.
- W2022753652 cites W2036228531 @default.
- W2022753652 cites W2038221636 @default.
- W2022753652 cites W2039285811 @default.
- W2022753652 cites W2039724227 @default.
- W2022753652 cites W2042410778 @default.
- W2022753652 cites W2045180389 @default.
- W2022753652 cites W2050551646 @default.
- W2022753652 cites W2055039037 @default.
- W2022753652 cites W2056678948 @default.
- W2022753652 cites W2057818978 @default.
- W2022753652 cites W2058396154 @default.
- W2022753652 cites W2064161559 @default.
- W2022753652 cites W2070083719 @default.
- W2022753652 cites W2078129863 @default.
- W2022753652 cites W2079406092 @default.
- W2022753652 cites W2079939615 @default.
- W2022753652 cites W2081386962 @default.
- W2022753652 cites W2081589974 @default.
- W2022753652 cites W2094870622 @default.
- W2022753652 cites W2096090406 @default.
- W2022753652 cites W2097082866 @default.
- W2022753652 cites W2101948750 @default.
- W2022753652 cites W2110902221 @default.
- W2022753652 cites W2111233884 @default.
- W2022753652 cites W2115671819 @default.
- W2022753652 cites W2116414711 @default.
- W2022753652 cites W2119410682 @default.
- W2022753652 cites W2129097378 @default.
- W2022753652 cites W2130382451 @default.
- W2022753652 cites W2138690749 @default.
- W2022753652 cites W2146915322 @default.
- W2022753652 cites W2147659195 @default.
- W2022753652 cites W2155623382 @default.
- W2022753652 cites W2164549762 @default.
- W2022753652 cites W2169406722 @default.
- W2022753652 cites W2170051572 @default.
- W2022753652 cites W2326995521 @default.
- W2022753652 cites W2339914498 @default.
- W2022753652 doi "https://doi.org/10.1016/j.neuroscience.2009.05.023" @default.
- W2022753652 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19463906" @default.
- W2022753652 hasPublicationYear "2009" @default.
- W2022753652 type Work @default.
- W2022753652 sameAs 2022753652 @default.
- W2022753652 citedByCount "77" @default.
- W2022753652 countsByYear W20227536522012 @default.
- W2022753652 countsByYear W20227536522013 @default.
- W2022753652 countsByYear W20227536522014 @default.
- W2022753652 countsByYear W20227536522015 @default.
- W2022753652 countsByYear W20227536522016 @default.
- W2022753652 countsByYear W20227536522017 @default.
- W2022753652 countsByYear W20227536522018 @default.
- W2022753652 countsByYear W20227536522019 @default.
- W2022753652 countsByYear W20227536522020 @default.
- W2022753652 countsByYear W20227536522021 @default.
- W2022753652 countsByYear W20227536522022 @default.