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- W2022753987 abstract "Accumulating evidence suggests small non-coding RNAs (microRNAs) play important roles in human cancer progression. In the present study, we found miR-150 was overexpressed in gastric cancer cell lines and tissues. Ectopic expression of miR-150 promoted tumorigenesis and proliferation of gastric cancer cells. Luciferase reporter assay demonstrated that EGR2 was a direct target of miR-150. Collectively, our study demonstrated that overexpression of miR-150 in gastric cancer could promote proliferation and growth of cancer cells at least partially through directly targeting the tumor-suppressor EGR2, suggesting a potential strategy for the development of miRNA-based treatment of gastric cancer." @default.
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- W2022753987 date "2010-02-01" @default.
- W2022753987 modified "2023-09-27" @default.
- W2022753987 title "MiR-150 promotes gastric cancer proliferation by negatively regulating the pro-apoptotic gene EGR2" @default.
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- W2022753987 doi "https://doi.org/10.1016/j.bbrc.2009.12.182" @default.
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