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- W2022754235 abstract "Summary Rabbits were injected intraperitoneally with 3 or 6 mg of paraquat/kg/day for a period of 3, 7, and 14 days. The treated rabbits showed a decrease in acidic phospholipids in liver at 3 and 14 days with 3 or 6 mg/kg/day of paraquat treatment. The percentage of total sugar in liver total lipids decreased significntly at 3 days of treatment with 3 mg PQ/kg/day but was little affected in the kidneys. The rtio between saturated fatty acids and unsaturated fatty acids of liver decreased at 3 days of treatment with 3 or 6 mg PQ/kg/day. In kidney, this ratio decreased at 3 days in response to 3 mg PQ/kg/day. Histological studies revealed the presence of severe tissue injuries mainly in lungs and to a lesser extent in liver of PQ treated rabbits. These results indicate, contrary to the earlier reports, that rabbits are susceptible to paraquat toxicity with the development of pulmonary fibrosis. Notes Present address: Plant Growth Laboratory, Wickson Hall, University of California, Davis, CA 95616, U.S.A. All correspondence should be addressed to this address." @default.
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- W2022754235 date "1988-12-01" @default.
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- W2022754235 title "Effect of paraquat on phospholipids and fatty acids in liver and kidney of rabbits" @default.
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