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• W2022755206 abstract "Despite the extensive use of intrathecal morphine infusion for pain, no systematic safety studies exist on its effects in high concentrations. The authors assessed the effects of morphine and clonidine given 28 days intrathecally in dogs.Beagles with lumbar intrathecal catheters received solutions delivered by a vest-mounted infusion pump. Six groups (n = 3 each) received infusions (40 microl/h) of saline or 1.5, 3, 6, 9, or 12 mg/day of morphine for 28 days. Additional groups received morphine at 40 microl/h (1.5 mg/day) plus clonidine (0.25-1.0 mg/day) or clonidine alone at 100 microg/h (4.8 mg/day).In animals receiving 9 or 12 mg/day morphine, allodynia was observed shortly after initiation of infusion. A concentration-dependent increase in hind limb dysfunction evolved over the infusion interval. Necropsy revealed minimal reactions in saline animals. At the higher morphine concentrations (all dogs receiving 12 mg/day), there was a local inflammatory mass at the catheter tip that produced significant local tissue compression. All animals with motor dysfunction displayed masses, although all animals with masses did not show motor dysfunction. The mass, arising from the dura-arachnoid layer, consisted of multifocal accumulations of neutrophils, monocytes, macrophages, and plasma cells. Inflammatory cells and endothelial cells displayed significant IL1beta, TNFalpha, iNOS, and eNOS immunoreactivity. No evidence of bacterial or fungal involvement was detected. There were no other changes in spinal morphologic characteristics. In four other groups of dogs, clonidine alone had no effect and in combination with morphine reduced the morphine reaction.The authors found that high intrathecal morphine concentrations lead to aseptic intrathecal inflammatory masses. The lack of effect of clonidine and the possible suppressive effects of clonidine on the local reaction suggest the utility of such coadministration." @default.
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• W2022755206 date "2003-07-01" @default.
• W2022755206 modified "2023-10-12" @default.
• W2022755206 title "Chronically Infused Intrathecal Morphine in Dogs" @default.
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• W2022755206 cites W1560114165 @default.
• W2022755206 cites W1560119701 @default.
• W2022755206 cites W1582607439 @default.
• W2022755206 cites W1600804236 @default.
• W2022755206 cites W1771060587 @default.
• W2022755206 cites W1829298682 @default.
• W2022755206 cites W1856798736 @default.
• W2022755206 cites W190824416 @default.
• W2022755206 cites W1964941501 @default.
• W2022755206 cites W1965105067 @default.
• W2022755206 cites W1966237369 @default.
• W2022755206 cites W1967638702 @default.
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• W2022755206 cites W1969833860 @default.
• W2022755206 cites W1971491668 @default.
• W2022755206 cites W1977986376 @default.
• W2022755206 cites W1981360039 @default.
• W2022755206 cites W1982665548 @default.
• W2022755206 cites W1987117573 @default.
• W2022755206 cites W1989423171 @default.
• W2022755206 cites W1996773684 @default.
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• W2022755206 cites W2005030884 @default.
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• W2022755206 cites W2008178649 @default.
• W2022755206 cites W2009303511 @default.
• W2022755206 cites W2009976246 @default.
• W2022755206 cites W2012031475 @default.
• W2022755206 cites W2019350224 @default.
• W2022755206 cites W2020818747 @default.
• W2022755206 cites W2025602376 @default.
• W2022755206 cites W2028606945 @default.
• W2022755206 cites W2035191176 @default.
• W2022755206 cites W2039728795 @default.
• W2022755206 cites W2039812684 @default.
• W2022755206 cites W2040725197 @default.
• W2022755206 cites W2043516252 @default.
• W2022755206 cites W2048145349 @default.
• W2022755206 cites W2051998790 @default.
• W2022755206 cites W2053629745 @default.
• W2022755206 cites W2063260273 @default.
• W2022755206 cites W2066216207 @default.
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• W2022755206 cites W2074052843 @default.
• W2022755206 cites W2076428797 @default.
• W2022755206 cites W2076664459 @default.
• W2022755206 cites W2088344710 @default.
• W2022755206 cites W2092006466 @default.
• W2022755206 cites W2105961368 @default.
• W2022755206 cites W2144504048 @default.
• W2022755206 cites W2149200346 @default.
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• W2022755206 cites W2161744383 @default.
• W2022755206 cites W2166866341 @default.
• W2022755206 cites W2170257510 @default.
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• W2022755206 doi "https://doi.org/10.1097/00000542-200307000-00028" @default.
• W2022755206 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12826864" @default.
• W2022755206 hasPublicationYear "2003" @default.
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