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• W2022755588 endingPage "468" @default.
• W2022755588 startingPage "457" @default.
• W2022755588 abstract "In this study, 5-chloro-3H-spiro-[1,3-benzothiazole-2,3′-indole]-2′(1′H)-one derivatives 3a–l were synthesized by the reaction of 1H-indole-2,3-diones 1a–l with 2-amino-4-chlorothiophenol 2 in ethanol. 3a–l were tested for their abilities to inhibit lipid peroxidation (LP), scavenge DPPH• and ABTS•+ radicals, and to reduce Fe3+ to Fe2+. Most of the tested compounds exhibited potent scavenging activities against ABTS•+ radical, reducing powers and strong inhibitory capacity on LP. 3 a, 3 d, 3e, 3h, 3j and 3 k chosen as prototypes were evaluated in the National Cancer Institute’s in vitro primary anticancer assay. The greatest growth inhibitions were observed against a non-small cell lung cancer cell line HOP-92 for R1-fluoro substituted 3 d and a renal cancer cell line RXF-393 for R-chloro substituted 3 e in the primary screen." @default.
• W2022755588 created "2016-06-24" @default.
• W2022755588 creator A5042853170 @default.
• W2022755588 creator A5072621836 @default.
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• W2022755588 date "2013-06-05" @default.
• W2022755588 modified "2023-10-16" @default.
• W2022755588 title "New spiroindolinones bearing 5-chlorobenzothiazole moiety" @default.
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• W2022755588 doi "https://doi.org/10.3109/14756366.2013.800058" @default.
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