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• W2022756362 abstract "The universe of painful Na-channelopathies--human disorders caused by mutations in voltage-gated sodium channels--has recently expanded in three dimensions. We now know that mutations of sodium channels cause not only rare genetic 'model disorders' such as inherited erythromelalgia and channelopathy-associated insensitivity to pain but also common painful neuropathies. We have learned that mutations of NaV1.8, as well as mutations of NaV1.7, can cause painful Na-channelopathies. Moreover, recent studies combining atomic level structural models and pharmacogenomics suggest that the goal of genomically guided pain therapy may not be unrealistic." @default.
• W2022756362 created "2016-06-24" @default.
• W2022756362 creator A5002957653 @default.
• W2022756362 date "2013-07-01" @default.
• W2022756362 modified "2023-10-14" @default.
• W2022756362 title "Painful Na-channelopathies: an expanding universe" @default.
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• W2022756362 doi "https://doi.org/10.1016/j.molmed.2013.04.003" @default.
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