FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022757268> ?p ?o ?g. }

• W2022757268 endingPage "123" @default.
• W2022757268 startingPage "115" @default.
• W2022757268 abstract "Chronic manganese exposure leads to accumulation in brain mainly in the basal ganglia. Continuous incorporation finally causes neural damage (Manganism, Mn-PD) with disease pattern comparable to idiopathic Parkinson's disease (I-PD). Obviously, Mn is transported by an active mechanism across the blood–brain barrier (BBB) into the brain, but the exact transport mechanism is still not completely understood. The transferrin receptor shuttle is involved but it seems that this is not the only mechanism. Excretion of Mn follows slow simple diffusion. The exact transport mechanism is still unknown. Mn-metabolism involves a multiplicity of Mn species specifically affecting Mn-homeostasis. Low molecular mass (LMM) Mn species potentially facilitate Mn accumulation in brain. Therefore, this paper investigated the formation and distribution of Mn- and Fe-Species in vivo (Sprague–Dawley rats) after a single intravenous (i.v.) injection of a non-toxic dose of MnCl2∙ 4H2O. Speciation analysis used a specifically developed sample preparation under cryogenic conditions and was performed with size exclusion chromatography online coupled to inductively coupled plasma-mass spectrometry (SEC-ICP-MS). The sample preparation method was previously shown to maintain species stability at enhanced extraction efficiency. One hour after i.v. injection overload of native Mn-carriers (Mn–transferrin) and formation of LMM Mn species, eluting at the retention time (RT) of Mn–citrate, were found in serum. After four days, serum and feces seemed to be Mn-cleared, but brain and kidney showed significantly elevated Mn levels. Even in lung and muscle tissue Mn was increased, but to a smaller extent. Accumulation of Mn especially in brain and kidney originated from increased concentrations of inorganic Mn and Mn bound to LMM Mn species. Iron status and iron species pattern appeared to be completely unaffected from i.v. injected Mn. The results underlined that specifically LMM-Mn-compounds permeated the BBB and accumulated in brain and kidney. It is discussed that kidney may play a regulatory role in the homeostasis of LMM Mn species." @default.
• W2022757268 created "2016-06-24" @default.
• W2022757268 creator A5014634459 @default.
• W2022757268 creator A5022551677 @default.
• W2022757268 creator A5025694365 @default.
• W2022757268 creator A5035801139 @default.
• W2022757268 date "2012-11-01" @default.
• W2022757268 modified "2023-10-18" @default.
• W2022757268 title "Manganese and iron species in Sprague–Dawley rats exposed with MnCl2∙4H2O (i.v.)" @default.
• W2022757268 cites W1583636275 @default.
• W2022757268 cites W1965934540 @default.
• W2022757268 cites W1969704550 @default.
• W2022757268 cites W1974658373 @default.
• W2022757268 cites W1975068341 @default.
• W2022757268 cites W1986305862 @default.
• W2022757268 cites W1989484896 @default.
• W2022757268 cites W1990790739 @default.
• W2022757268 cites W1992507434 @default.
• W2022757268 cites W2000934225 @default.
• W2022757268 cites W2001567949 @default.
• W2022757268 cites W2005001452 @default.
• W2022757268 cites W2006857006 @default.
• W2022757268 cites W2007935011 @default.
• W2022757268 cites W2011995865 @default.
• W2022757268 cites W2014721161 @default.
• W2022757268 cites W2016557044 @default.
• W2022757268 cites W2017462865 @default.
• W2022757268 cites W2018217993 @default.
• W2022757268 cites W2022871657 @default.
• W2022757268 cites W2025063442 @default.
• W2022757268 cites W2033500770 @default.
• W2022757268 cites W2035232669 @default.
• W2022757268 cites W2052257773 @default.
• W2022757268 cites W2054566540 @default.
• W2022757268 cites W2055844985 @default.
• W2022757268 cites W2057806371 @default.
• W2022757268 cites W2059484007 @default.
• W2022757268 cites W2062214745 @default.
• W2022757268 cites W2063899787 @default.
• W2022757268 cites W2065938547 @default.
• W2022757268 cites W2067620208 @default.
• W2022757268 cites W2071496824 @default.
• W2022757268 cites W2071986178 @default.
• W2022757268 cites W2072332791 @default.
• W2022757268 cites W2077328057 @default.
• W2022757268 cites W2080687021 @default.
• W2022757268 cites W2083927739 @default.
• W2022757268 cites W2087607022 @default.
• W2022757268 cites W2088886257 @default.
• W2022757268 cites W2089656683 @default.
• W2022757268 cites W2096744161 @default.
• W2022757268 cites W2102595104 @default.
• W2022757268 cites W2135848716 @default.
• W2022757268 cites W2139599219 @default.
• W2022757268 cites W2148331174 @default.
• W2022757268 cites W2151081293 @default.
• W2022757268 cites W2152810790 @default.
• W2022757268 cites W2154410930 @default.
• W2022757268 cites W2164277737 @default.
• W2022757268 cites W819310579 @default.
• W2022757268 doi "https://doi.org/10.1016/j.microc.2012.03.015" @default.
• W2022757268 hasPublicationYear "2012" @default.
• W2022757268 type Work @default.
• W2022757268 sameAs 2022757268 @default.
• W2022757268 citedByCount "10" @default.
• W2022757268 countsByYear W20227572682013 @default.
• W2022757268 countsByYear W20227572682014 @default.
• W2022757268 countsByYear W20227572682015 @default.
• W2022757268 countsByYear W20227572682016 @default.
• W2022757268 countsByYear W20227572682018 @default.
• W2022757268 crossrefType "journal-article" @default.
• W2022757268 hasAuthorship W2022757268A5014634459 @default.
• W2022757268 hasAuthorship W2022757268A5022551677 @default.
• W2022757268 hasAuthorship W2022757268A5025694365 @default.
• W2022757268 hasAuthorship W2022757268A5035801139 @default.
• W2022757268 hasConcept C10146269 @default.
• W2022757268 hasConcept C112705442 @default.
• W2022757268 hasConcept C12554922 @default.
• W2022757268 hasConcept C150903083 @default.
• W2022757268 hasConcept C162356407 @default.
• W2022757268 hasConcept C165697059 @default.
• W2022757268 hasConcept C178790620 @default.
• W2022757268 hasConcept C185592680 @default.
• W2022757268 hasConcept C207001950 @default.
• W2022757268 hasConcept C22814914 @default.
• W2022757268 hasConcept C32264632 @default.
• W2022757268 hasConcept C43617362 @default.
• W2022757268 hasConcept C528890316 @default.
• W2022757268 hasConcept C55493867 @default.
• W2022757268 hasConcept C86803240 @default.
• W2022757268 hasConcept C98274493 @default.
• W2022757268 hasConceptScore W2022757268C10146269 @default.
• W2022757268 hasConceptScore W2022757268C112705442 @default.
• W2022757268 hasConceptScore W2022757268C12554922 @default.
• W2022757268 hasConceptScore W2022757268C150903083 @default.
• W2022757268 hasConceptScore W2022757268C162356407 @default.
• W2022757268 hasConceptScore W2022757268C165697059 @default.
• W2022757268 hasConceptScore W2022757268C178790620 @default.

• next