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- W2022757636 abstract "This chapter discusses the programmed cell death (PCD) in the pathogenesis of autoimmune diabetes. Diabetes is one of the most common chronic diseases and a major cause of morbidity and mortality in the industrialized world. Diabetes manifests as a set of metabolic abnormalities, all of which can be attributed to insulin deficiency. This deficiency may be total and absolute (type 1 diabetes) or partial and relative to increased requirements resulting from insulin resistance. The insulin-secreting β-cells make up the bulk of the islets of Langerhans, small clusters of endocrine cells embedded within the acinae of the exocrine pancreas. Type 1 diabetes results from specific destruction of all or most of the β-cell mass over a relatively brief period of time. It is evident that this destruction has an autoimmune basis. The predisposition to autoimmune diabetes in both animal models is inherited as a polygenic trait and can be modified by a wide variety of environmental conditions. Patients with long-standing type 1 diabetes have very few or no detectable β-cells at autopsy, and that antibodies against several components of the β-cell can be detected in serum for some time before the onset of the metabolic manifestations of insulin deficiency." @default.
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- W2022757636 date "1993-08-01" @default.
- W2022757636 modified "2023-09-27" @default.
- W2022757636 title "The possible link between insulin dependent (juvenile) diabetes mellitus and dietary cow milk" @default.
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- W2022757636 doi "https://doi.org/10.1016/0009-9120(93)90131-o" @default.
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