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• W2022757916 abstract "The trans-activation potential of herpes simplex virus (HSV) VP16, either alone or in combination with interferon regulatory factor 1 (IRF-1), was examined using hybrid promoters containing different regulatory elements from the interferon-beta promoter. Coexpression of HSV VP16 and IRF-1 differentially activated the AAGTGA hexamer construct Th(2), the AAAGGA hexamer Thm(2) construct, and the natural IFN-beta promoter. Surprisingly, high concentrations of IRF-1 inhibited expression of the PRDII containing reporter P2(1)/CAT. These results indicate that trans-activation by HSV VP16, acting through distinct cellular transcription factors, may be involved in stimulation of IFN-beta regulatory domains." @default.
• W2022757916 created "2016-06-24" @default.
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• W2022757916 date "1992-02-01" @default.
• W2022757916 modified "2023-09-27" @default.
• W2022757916 title "Differential response of human interferon-β promoter elements to trans-activation by HSV VP16 and IRF-1" @default.
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• W2022757916 doi "https://doi.org/10.1016/0042-6822(92)90043-o" @default.
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