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• W2022758308 abstract "Intravenous injection of 3-33 nmol/kg of substance P (SP) caused pressor and tachycardic responses in anesthetized rats. The responses were not blocked by a ganglion nicotinic receptor antagonist or by pithing. Pretreatment with reserpine blocked both responses. beta-Adrenoceptor blockade attenuated only the tachycardic response, and alpha-adrenoceptor blockade attenuated only the pressor response. These findings indicated that the effects of SP to increase blood pressure and heart rate are due to sympathetic ganglion stimulation. Studies with adrenalectomized rats showed that stimulation of the adrenals by SP contributes to both responses but makes a greater contribution to the tachycardic response. These observations raise the possibility that the tachykinin innervation of sympathetic ganglia and the adrenal medulla may be involved in the local regulation of blood pressure and heart rate." @default.
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• W2022758308 date "1995-01-01" @default.
• W2022758308 modified "2023-10-14" @default.
• W2022758308 title "Pressor and tachycardic responses to intravenous substance P in anesthetized rats" @default.
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• W2022758308 doi "https://doi.org/10.1016/0196-9781(95)02049-7" @default.
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