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- W2022758600 abstract "Thermoresponsive block copolymers based on poly(ethylene oxide) (PEO) and poly(N-isopropyl acrylamide) (PNIPAM) containing azlactone groups along the backbone and at the chain-end of the macromolecular chain were synthesized by statistically reversible addition–fragmentation chain transfer (RAFT) copolymerization and by using a combination of RAFT polymerization and thiol–ene Michael addition. Well-defined poly(ethylene oxide)-b-poly(2-vinyl-4,4-dimethylazlactone-co-N-isopropyl acrylamide) (PEO-b-P(VDM-co-NIPAM)) block copolymers and azlactone-terminated poly(ethylene oxide)-b-poly(N-isopropyl acrylamide) (PEO-b-PNIPAM-VDM) diblock copolymers with low polydispersity indices (PDIs ≤ 1.10) were prepared and fully characterized by 1H NMR spectroscopy, FT-IR spectroscopy, and SEC. Such PEO-b-P(VDM-co-NIPAM) block copolymers and azlactone-terminated PEO-b-PNIPAM block copolymers present tunable lower critical solution temperature (LCST) depending on PEO, PNIPAM, and PVDM molar ratios. The reactivity of the PEO44-b-P(VDM20-co-NIPAM80) copolymer (Mn,NMR = 14 200 g mol−1, PDI = 1.08) and of the PEO44-b-PNIPAM101-VDM copolymer (Mn,NMR = 13 700 g mol−1, PDI = 1.08) was studied with lysozyme as a model protein. A bioconjugate with a higher apparent molecular weight was obtained with the PEO44-b-P(VDM20-co-NIPAM80) copolymer in comparison with the one obtained using the PEO44-b-PNIPAM101-VDM copolymer as shown by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). The results suggest promising applications of azlactone-functionalized polymers within the field of bioconjugation." @default.
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- W2022758600 date "2013-01-01" @default.
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- W2022758600 title "Thermoresponsive block copolymers containing reactive azlactone groups and their bioconjugation with lysozyme" @default.
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- W2022758600 doi "https://doi.org/10.1039/c2py20714a" @default.
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