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• W2022759858 abstract "Studies in vitro indicate that group X secretory phospholipase A2 (GX sPLA2) potently releases arachidonic acid (AA) and lysophosphatidylcholine from mammalian cell membranes. To define the function of GX sPLA2 in vivo, our laboratory recently generated C57BL/6 mice with targeted deletion of GX sPLA2 (GX−/− mice). When fed a normal rodent diet, GX−/− mice gained significantly more weight and had increased adiposity compared to GX+/+ mice, which was not attributable to alterations in food consumption or energy expenditure. When treated with adipogenic stimuli ex vivo, stromal vascular cells isolated from adipose tissue of GX−/− mice accumulated significantly more (20%) triglyceride compared to cells from GX+/+ mice. Conversely, overexpression of GX sPLA2, but not catalytically inactive GX sPLA2, resulted in a significant 50% reduction in triglyceride accumulation in OP9 adipocytes. The induction of genes encoding adipogenic proteins (PPARγ, SREBP-1c, SCD1, and FAS) was also significantly blunted by 50–80% in OP9 cells overexpressing GX sPLA2. Activation of the liver X receptor (LXR), a nuclear receptor known to up-regulate adipogenic gene expression, was suppressed in 3T3-L1 and OP9 cells when GX sPLA2 was overexpressed. Thus, hydrolytic products generated by GX sPLA2 negatively regulate adipogenesis, possibly by suppressing LXR activation.—Li, X., Shridas, P., Forrest, K., Bailey, W., Webb, N. R. Group X secretory phospholipase A2 negatively regulates adipogenesis in murine models. FASEB J. 24, 4313–4324 (2010). www.fasebj.org" @default.
• W2022759858 created "2016-06-24" @default.
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• W2022759858 date "2010-06-28" @default.
• W2022759858 modified "2023-10-16" @default.
• W2022759858 title "Group X secretory phospholipase A₂negatively regulates adipogenesis in murine models" @default.
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• W2022759858 doi "https://doi.org/10.1096/fj.10-154716" @default.
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